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The mechanism of β-cyclodextrin on the 11β-hydroxylation biotransformation of steroid
Ist Teil von
2010 3rd International Conference on Biomedical Engineering and Informatics, 2010, Vol.5, p.1964-1967
Ort / Verlag
IEEE
Erscheinungsjahr
2010
Quelle
IEEE/IET Electronic Library
Beschreibungen/Notizen
In this paper, the biotransformation of 17α-hydroxypregna-4-ene-3 20-dione-21-acetate (RSA) and 17α-hydroxypregna-4-ene-3 20-dione (RS) by Absidia coerulea AC307 was selected as a model system for evaluating the mechanism of β-cyclodextrin (β-CD) on the the steroid 11β-hydroxylation biotransformation process. It was found that the addition of cyclodextrin to RS and RSA biotransformation systems could effectively increase the speed of biotransformation and decrease the reactant's absorption by microorganism. There may be some relation between the two kinds affection induced by cyclodextrin, and the idea can be validated by Shewmon P G's theory. It showed that cyclodextrin can affect the steroid-permeating capability of the microorganism, and that seemed to be favourable for reactant entered into the microorganism.