Details

Autor(en) / Beteiligte

• Otte, W M
• Dijkhuizen, R M
• Stam, C J
• van der Marel, K
• van Meer, M P A
• Viergever, M A
• Braun, K P J

Titel

Spatiotemporal network alterations in experimental focal cortical epilepsy: MRI-based longitudinal functional connectivity and weighted graph analysis

Ist Teil von

• 2010 IEEE International Symposium on Biomedical Imaging: From Nano to Macro, 2010, p.888-891

Ort / Verlag

IEEE

Erscheinungsjahr

2010

Quelle

IEEE/IET Electronic Library (IEL)

Beschreibungen/Notizen

• There is increasing evidence that the topology of brain networks may be changed in epilepsy. In particular, a random topology has been suggested as an explanation for lower seizure thresholds. To test this hypothesis, we assessed focal epileptic and healthy networks over time using resting state functional MRI and weighted graph theoretical analysis in a rat model. Brain networks in focal epilepsy were globally affected, toward a more ordered network topology. Networks largely normalized at ten weeks after epilepsy induction. Graph analysis provides a promising method to explore dynamical network alterations in epilepsy.