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There is consensus among preparedness experts, including epidemiologists, that another influenza pandemic is imminent (R.I. Webby and R.G. Webster, 2003). An influenza pandemic is a worldwide spread of a new, highly contagious strain of flu where little or no immunity exists and a vaccine is unavailable. The development of a preparedness plan before the next pandemic outbreak is vital because past pandemics have led to millions of American casualties and substantial economic losses. This project develops a set of risk mitigation strategies in the form of mask distribution for reducing the impact of an influenza outbreak in the Hampton Roads Planning District (HRPD). The project found a significant reduction in illnesses, hospitalizations, deaths, worker absenteeism, economic losses and medical surge for all strategies. However, an analysis of regional supply concludes that only partial mask strategies are feasible.