Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Ergebnis 9 von 118
2022 26th International Conference Information Visualisation (IV), 2022, p.406-411
2022

Details

Autor(en) / Beteiligte
Titel
Identifying the Correlation between Alzheimer and type 2 Diabetes
Ist Teil von
  • 2022 26th International Conference Information Visualisation (IV), 2022, p.406-411
Ort / Verlag
IEEE
Erscheinungsjahr
2022
Link zum Volltext
Quelle
IEL
Beschreibungen/Notizen
  • In recent years it has been assessed that in people with type 2 diabetes the likelihood of developing Alzheimer's disease increases by more than 50%. The purpose of the analysis proposed in this paper is to identify visually the correlation between Alzheimer's disease and type 2 diabetes and determine whether Alzheimer's disease is a form of brain diabetes mellitus. A dataset containing genomic microarray data relating to the two diseases is used for the analysis. First, we conduct an exploratory analysis using clustering techniques to perform a first screening of the samples and divide them into two different clusters. Then, we propose a predictive model for the classification and identify the genes equally expressed in the two types of samples. This makes it possible to select genes with significant values for the research in progress, on which pathway analysis must be performed to identify the classes they belong to. We also study the gene expression alterations of genes belonging to a specific pathway to determine if the differential expression is statistically significant. We provide a visual representation of connections in the pathways of both the diseases. Results indicate that there is a set of genes of significant importance for both type 2 diabetes and Alzheimer's disease, but that there is also a significant correlation with other neurodegenerative diseases. Consequently, it is possible to define the Alzheimer's disease as a form of cerebral diabetes mellitus.
Sprache
Englisch
Identifikatoren
eISSN: 2375-0138
DOI: 10.1109/IV56949.2022.00073
Titel-ID: cdi_ieee_primary_10017946

Weiterführende Literatur

Empfehlungen zum selben Thema automatisch vorgeschlagen von bX