Details

Autor(en) / Beteiligte

• Chiu, Yu-Cheng
• Ho, Meng-Hsing
• Chen, Teng-Wei
• Hsieh, Chung-Bao
• Fan, Hsiu-Lung
• Haberal,Mehmet

Titel

Twice-Weekly Tacrolimus Can Overcome Pharmacologic Interaction and Help in the Successful Treatment of Pulmonary Aspergillosis in a Liver Transplant Recipient

Ist Teil von

• Experimental and clinical transplantation, 2019-12, Vol.17 (6), p.838-840

Ort / Verlag

Başkent Üniversitesi

Erscheinungsjahr

2019

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Drug-drug interactions between azoles and calcineurin inhibitors can cause issues for organ transplant specialists. Clinical practice guidelines for the treatment of solid-organ transplant recipients with invasive aspergillosis infection are lacking. Here, we present a patient who developed pulmonary aspergillosis after liver transplant. The patient had prolonged treatment with echinocandin that was not effective. A drug-drug interaction between azoles and tacrolimus caused issues for the clinical physician. We adjusted the doses, and the patient was successfully treated. A reduction in the tacrolimus dose, intensive monitoring of associated parameters, and elimination of risk exposures are important for a favorable outcome.