Details

Autor(en) / Beteiligte

• Katz, Assaf
• Orellana, Omar

Titel

Glutamyl-tRNA in Bacteria. Multiple Identities for Multiple Functions

Ist Teil von

• Croatica chemica acta, 2012-05, Vol.85 (2), p.159-169

Ort / Verlag

Zagreb: Croatica Chemica Acta

Erscheinungsjahr

2012

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The existence of aminoacyl-tRNAs was predicted during the late 50s as molecules that transfer specific amino acids for protein synthesis. Today we know that, in addition to protein synthesis, these molecules can also participate in several other cellular functions. One of these aminoacyl-tRNAs, glutamyl-tRNA, can participate in at least three functions in bacteria: biosynthesis of glutaminyl-tRNA, tetrapyrroles and proteins. In this article we discuss how bacterial cells manage to distribute glutamyl-tRNA among all these functions. Proteins involved in each pathway recognize different features of the tRNA which allows them to use only the correct glutamyl-tRNA species. Also, the formation of macromolecular complexes allows the utilization of each of these species by the correct proteins. This compartmentalization is critical for bacterial fitness as it prevents the incorporation of intermediates in the incorrect pathway.(doi: 10.5562/cca1830) Keywords: [tRNA.sup.Glu], molecular recognition, glutamyl-tRNA synthetase, amido transferase, elongation factor Tu, glutamyl-tRNA reductase