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We describe two patients with histologically proven pulmonary
Langerhansâ cell histiocytosis in whom radiologic improvement occurred
following smoking cessation. The patients had 23- and 25-pack-year
smoking histories, respectively. High-resolution CT revealed multiple
small nodules, located predominantly in the upper and middle lung
fields. There was a close temporal relationship between smoking
cessation and radiologic improvement.
Abbreviations: BLPs = bombesin-like peptides;
CD10/NEP = CD10/neutral endopeptidase; CRP = C-reactive protein;
D lco = diffusing capacity of the lung for carbon
monoxide; HRCT = high-resolution CT; LCH = Langerhansâ cell
histiocytosis; TLC = total lung capacity