Details

Autor(en) / Beteiligte

• PETTIT, ELIZABETH J

Titel

Cytosolic Free Calcium and the Cytoskeleton in the Control of Leukocyte Chemotaxis

Ist Teil von

• Physiological reviews, 1998-10, Vol.78 (4), p.949-967

Ort / Verlag

United States: Am Physiological Soc

Erscheinungsjahr

1998

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• ELIZABETH J. PETTIT AND FREDRIC S. FAY Biomedical Imaging Group, University of Massachusetts Medical Center, Worcester, Massachusetts Pettit, Elizabeth J., and Frederic S. Fay. Cytosolic Free Calcium and the Cytoskeleton in the Control of Leukocyte Chemotaxis. Physiol. Rev. 78: 949-967, 1998.   In response to a chemotactic gradient, leukocytes extravasate and chemotax toward the site of pathogen invasion. Although fundamental in the control of many leukocyte functions, the role of cytosolic free Ca 2+ in chemotaxis is unclear and has been the subject of debate. Before becoming motile, the cell assumes a polarized morphology, as a result of modulation of the cytoskeleton by G protein and kinase activation. This morphology may be reinforced during chemotaxis by the intracellular redistribution of Ca 2+ stores, cytoskeletal constituents, and chemoattractant receptors. Restricted subcellular distributions of signaling molecules, such as Ca 2+ , Ca 2+ /calmodulin, diacylglycerol, and protein kinase C, may also play a role in some types of leukocyte. Chemotaxis is an essential function of most cells at some stage during their development, and a deeper understanding of the molecular signaling and structural components involved will enable rational design of therapeutic strategies in a wide variety of diseases.