Details

Autor(en) / Beteiligte

• Bai, Tony R
• Bates, Jason H. T
• Brusasco, Vito
• Camoretti-Mercado, Blanca
• Chitano, Pasquale
• Deng, Lin Hong
• Dowell, Maria
• Fabry, Ben
• Ford, Lincoln E
• Fredberg, Jeffrey J
• Gerthoffer, William T
• Gilbert, Susan H
• Gunst, Susan J
• Hai, Chi-Ming
• Halayko, Andrew J
• Hirst, Stuart J
• James, Alan L
• Janssen, Luke J
• Jones, Keith A
• King, Greg G
• Lakser, Oren J
• Lambert, Rodney K
• Lauzon, Anne-Marie
• Lutchen, Kenneth R
• Maksym, Geoffrey N
• Meiss, Richard A
• Mijailovich, Srboljub M
• Mitchell, Howard W
• Mitchell, Richard W
• Mitzner, Wayne
• Murphy, Thomas M
• Pare, Peter D
• Schellenberg, R. Robert
• Seow, Chun Y
• Sieck, Gary C
• Smith, Paul G
• Smolensky, Alex V
• Solway, Julian
• Stephens, Newman L
• Stewart, Alastair G
• Tang, Dale D
• Wang, Lu

Titel

On the terminology for describing the length-force relationship and its changes in airway smooth muscle

Ist Teil von

• Journal of applied physiology (1985), 2004-12, Vol.97 (6), p.2029-2034

Ort / Verlag

Bethesda, MD: Am Physiological Soc

Erscheinungsjahr

2004

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• 1 James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada; 2 Departments of Medicine, Molecular Physiology, and Biophysics, University of Vermont, Burlington, Vermont; 3 Department of Internal Medicine, University of Genoa, Genoa, Italy; 4 Pulmonary Section, Department of Medicine, The University of Chicago, Chicago, Illinois; 5 Division of Pediatric Pulmonary Diseases, Duke University Medical Center, Durham, North Carolina; 6 Physiology Program, Harvard School of Public Health, Boston, Massachusetts; 7 Zentralinstitut fur Biomedizinische Technik, Erlangen, Germany; 8 Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana; 9 Department of Pharmacolgy, University of Nevada School of Medicine, Reno, Nevada; 10 Department of Cellular & Integrative Physiology, Indiana University School of Medicine, Indianapolis, Indiana; 11 Department of Molecular, Pharmacology, Physiology and Biotechnology, Brown University, Providence, Rhode Island; 12 Department of Physiology, University of Manitoba, Winnipeg, Canada; 13 Department of Asthma, Allergy, and Respiratory Science, The Guy's, King's College & St. Thomas' School of Medicine, King's College London, London, United Kingdom; 14 West Australia Sleep Disorder Research Institute, Sir Charles Gairdner Hospital, Nedland, Australia; 15 Department of Medicine, McMaster University, Hamilton, Ontario, Canada; 16 Department of Anesthesiology, Mayo Clinic and Foundation, Rochester, Minnesota; 17 The Woolcock Institute of Medical Research, St. Leonards, Australia; 18 Children's Memorial Hospital, Chicago, Illinois; 19 Institute of Fundamental Sciences-Physics, Palmerston North, New Zealand; 20 Department of Medicine, McGill University, Meakins-Christie Laboratories, Montreal, Quebec, Canada; 21 Biomedical Engineering, Boston University, Boston, Massachusetts; 22 School of Biomedical Engineering, Dalhousie University, Halifax, Nova Scotia, Canada; 23 Physiology M311, School of Biomedical and Chemical Sciences, University of Western Australia, Crawley, Australia; 24 Department of Physiology, Johns Hopkins University Blomberg School of Public Health, Baltimore, Maryland; 25 Department of Physiology & Biomedical Engineering, Mayo Clinic College of Medicine, Rochester, Minnesota; 26 Department of Pediatrics, Case Western Reserve University, Cleveland, Ohio; and 27 Department of Pharmacology, University of Melbourne, Victoria, Australia ABSTRACT The observation that the length-force relationship in airway smooth muscle can be shifted along the length axis by accommodating the muscle at different lengths has stimulated great interest. In light of the recent understanding of the dynamic nature of length-force relationship, many of our concepts regarding smooth muscle mechanical properties, including the notion that the muscle possesses a unique optimal length that correlates to maximal force generation, are likely to be incorrect. To facilitate accurate and efficient communication among scientists interested in the function of airway smooth muscle, a revised and collectively accepted nomenclature describing the adaptive and dynamic nature of the length-force relationship will be invaluable. Setting aside the issue of underlying mechanism, the purpose of this article is to define terminology that will aid investigators in describing observed phenomena. In particular, we recommend that the term "optimal length" (or any other term implying a unique length that correlates with maximal force generation) for airway smooth muscle be avoided. Instead, the in situ length or an arbitrary but clearly defined reference length should be used. We propose the usage of "length adaptation" to describe the phenomenon whereby the length-force curve of a muscle shifts along the length axis due to accommodation of the muscle at different lengths. We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously. smooth muscle contraction; adaptation; plasticity; cytoskeleton; contractile apparatus Address for reprint requests and other correspondence: C. Y. Seow, Dept. of Pathology/Laboratory Medicine, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Univ. of British Columbia, Vancouver, BC, Canada V6Z 1Y6 (E-mail: cseow{at}mrl.ubc.ca )