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Genetic Models in Applied Physiology: Invited Review: Identifying new mouse models of cardiovascular disease: a review of high-throughput screens of mutagenized and inbred strains
Ist Teil von
Journal of applied physiology (1985), 2003-04, Vol.94 (4), p.1650
Ort / Verlag
Am Physiological Soc
Erscheinungsjahr
2003
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
The Jackson Laboratory, Bar Harbor, Maine 04609
The mouse
is a proven model for studying human disease. Many strains exist that
exhibit either natural or engineered genetic variation and thereby
enable the elucidation of pathways involved in the development of
cardiovascular disease. Although those mouse models have been
fundamental to advancing our knowledge base, we are still at an early
stage in understanding how genes contribute to complex disorders. There
remains a need for new animal models that closely represent human
disease. To expedite their development, we have established the Center
for New Mouse Models of Heart, Lung, Blood, and Sleep Disorders at The
Jackson Laboratory. We are using a phenotype-driven approach to
identify mutations leading to atherosclerosis, hypertension, obesity,
blood disorders, lung dysfunction, thrombosis, and disordered sleep.
Our high-throughput, comprehensive phenotyping draws from two sources
for new models: 1 ) the natural variation among over 40 inbred mouse strains and 2 ) chemically induced, whole-genome
mutagenized mice. Here, we review our cardiovascular screens and
present some hypertensive, obese, and cardiovascular models identified
with this approach.
mutagenesis; Mouse Phenome Project
Sprache
Englisch
Identifikatoren
ISSN: 8750-7587
eISSN: 1522-1601
DOI: 10.1152/japplphysiol.01029.2002
Titel-ID: cdi_highwire_physiology_jap_94_4_1650
Format
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