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Diet restriction in rhesus monkeys lowers fasting and glucose-stimulated glucoregulatory end points
Ist Teil von
American journal of physiology: endocrinology and metabolism, 1995-05, Vol.268 (5), p.E941-E948
Ort / Verlag
United States
Erscheinungsjahr
1995
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
M. A. Lane, S. S. Ball, D. K. Ingram, R. G. Cutler, J. Engel, V. Read and G. S. Roth
Molecular Physiology and Genetics Section, Nathan Shock Laboratories, National Institute on Aging, National Institutes of Health, Baltimore 21224, USA.
Male rhesus monkeys (Macaca mulatta) of different age groups representing
the species life span were fed ad libitum or a 30% reduced calorie diet
over a 7-yr period. During the first 2-3 yr of this longitudinal study,
glucose and insulin levels were not altered by diet restriction (DR).
However, reductions in fasting blood glucose became apparent in DR animals
after 3-4 yr. At the end of the 6th yr of study, glycated hemoglobin was
measured, and intravenous glucose tolerance tests (IVGTTs) were conducted.
Maximum glucose levels reached during IVGTTs increased with age but were
lower in DR animals compared with controls. Several measures of the insulin
response (baseline, maximum, and integrated areas under curve) increased
with age and were lower in DR monkeys. With the exception of glycated
hemoglobin, which was not different in monkeys subjected to DR, these
findings confirm previous studies in rodents demonstrating that DR alters
glucose metabolism and may be related to the antiaging action of this
intervention.