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Increasing Incidence of Diabetes After Gestational Diabetes
Ist Teil von
Diabetes care, 2004-05, Vol.27 (5), p.1194-1199
Ort / Verlag
Alexandria: American Diabetes Association
Erscheinungsjahr
2004
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
Increasing Incidence of Diabetes After Gestational Diabetes
A long-term follow-up in a Danish population
Jeannet Lauenborg , MD 1 ,
Torben Hansen , MD, PHD 2 ,
Dorte Møller Jensen , MD, PHD 3 ,
Henrik Vestergaard , MD, DMSC 4 ,
Lars Mølsted-Pedersen , MD, DMSC 5 ,
Peter Hornnes , MD, DMSC 1 ,
Henning Locht , MD 6 ,
Oluf Pedersen , MD, DMSC 2 and
Peter Damm , MD, DMSC 1
1 Department of Obstetrics, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
2 Steno Diabetes Center, Gentofte, Denmark
3 Department of Endocrinology, Odense University Hospital, Odense, Denmark
4 Department of Endocrinology, Herlev University Hospital, Herlev, Denmark
5 Department of Obstetrics, Glostrup University Hospital, Glostrup, Denmark
6 Department of Autoimmunology, Statens Serum Institut, Copenhagen, Denmark
Address correspondence and reprint requests to Jeannet Lauenborg, MD, Department of Obstetrics, 4031, The Juliane Marie Centre
Rigshospitalet, Copenhagen University Hospital, Blegdamsvej 9, DK-2100 Copenhagen, Denmark. E-mail: jeannet{at}lauenb.org
Abstract
OBJECTIVE —To study the incidence of diabetes among women with previous diet-treated gestational diabetes mellitus (GDM) in the light
of the general increasing incidence of overweight and diabetes and to identify risk factors for the development of diabetes.
RESEARCH DESIGN AND METHODS —Women with diet-treated GDM during 1978–1985 (old cohort, n = 241, also followed up around 1990) or 1987–1996 (new cohort, n = 512) were examined in 2000–2002. Women were classified by a 2-h, 75-g oral glucose tolerance test according to the World
Health Organization criteria or an intravenous glucagon test supplemented by measurement of GAD antibodies. Historical data
from index-pregnancy and anthropometrical measurements were collected.
RESULTS —A total of 481 (63.9%) women were examined (median 9.8 years [interquartile range 6.4–17.2]) after index pregnancy. Diabetes
and impaired glucose tolerance (IGT)/impaired fasting glucose were present in 40.0 and 27.0% of women, respectively. In the
new cohort, 40.9% had diabetes compared with 18.3% in the old cohort at the 1990 follow-up ( P < 0.0005). Prepregnancy BMI was significantly higher in the new compared with the old cohort (26.0 [22.5–30.8] vs. 22.9 kg/m 2 [20.2–28.0], P < 0.0005). Among others, new-cohort membership, prepregnancy overweight (BMI ≥25 kg/m 2 ), and IGT postpartum were identified as independent predictors of diabetes by multiple logistic regression analyses.
CONCLUSIONS —The incidence of diabetes among Danish women with previous diet-treated GDM was very high and had more than doubled over
a 10-year period. This seems to be due to a substantial increase in BMI in women with GDM.
GADA, GAD antibody
GDM, gestational diabetes mellitus
IFG, impaired fasting glucose
IGT, impaired glucose tolerance
OGTT, oral glucose tolerance test
Footnotes
Accepted February 16, 2004.
Received October 30, 2003.
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