Details

Autor(en) / Beteiligte

• Bruel, Timothée
• Vrignaud, Lou-Léna
• Porrot, Françoise
• Planas, Delphine
• Puech, Julien
• Munier, Sandie
• Soulié, Cathia
• Zafilaza, Karen
• Molino, Diana
• Péré, Hélène
• Yordanov, Youri
• Veyer, David
• Carrat, Fabrice
• Schwartz, Olivier
• Marcelin, Anne-Geneviève
• Giraud, Valentin
• Cazenave-Roblot, Fance
• Martellosio Anne-Marie Ronchetti, Jean-Philippe
• Gabas, Thomas
• Housset, Pierre
• Pardon, Agathe
• Faucon, Anne-Laure
• Alric, Laurent
• Mourguet, Morgane
• Bonnet, Delphine
• Delobel, Pierre
• Beck, Colleen
• Boumaza, Xavier
• Delage, Claire
• Pires, Elisabete Gomes
• Cheminant, Morgane
• Anthony Chauvin, Nathalie Chavarot
• Cresta, Mélanie
• Pélagie Thibaut, Romain Gueneau
• Siguier, Martin
• Faycal, Antoine
• Brin, Cécile
• Djebara, Siham
• Sayon, Sophie
• Leducq, Vincent
• Malet, Isabelle
• Teyssou, Elisa
• Karine Lacombe, Adélie Gothland
• Chiarabini, Thibault
• Valin, Nadia
• Boize, Julien
• Thiébaud, Pierre-Clément
• Moreau, Marie
• Nathalie De Castro, Charlotte Billard
• Denis, Blandine
• Molina, Jean-Michel
• André Cabié, Lucia Etheve
• Cabras, Ornella
• François Vincent Dubee, Sandrine Pierre
• Pistone, Thierry
• Desclaux, Arnaud
• Festou, Benjamin
• Nathan Peiffer- Smadja, Delphine Chainier
• Thy, Michael
• Godard, Cindy
• Bouzid, Donia
• Ing, Vittiaroat
• Pereira, Laurent
• Pavlowsky, Thomas
• Boutoille, David
• Deschanvres, Colin
• Cailleaux, Marine
• Benezit, François
• Maillard, Anne
• François Coustilleres, Pierre Tattevin
• Vidal, Magali
• Sauvat, Léo
• Baronnet, Guillaume
• Florence Ader, Agnès Didier
• Perpoint, Thomas
• Conrad, Anne
• Chabert, Paul
• Loubet, Paul
• Mazet, Julien
• Remillon, Aline
• Albert Trinh-Duc, Pauline Bouquet
• Philippe Petua, Patrick Rispal
• Aurore Perrot, Julien Carillo
• Cougoul, Pierre
• Dion, Jérémie
• Mathieu Blot, Odile Rauzy
• Sixt, Thibault
• Moretto, Florian
• Charles, Carole
• Sophie Circosta, Lionel Piroth
• Leger, Lydia
• Arulananthan, Arulvani
• Lascoux, Carine
• Yazdan Yazdanpanah, Leia Becam
• Petrov-Sanchez, Ventzislava
• Le Mestre, Soizic
• Chau, Frédéric
• Soltana, Brahim
• Caille, Yvanie

Titel

Sotrovimab therapy elicits antiviral activities against Omicron BQ.1.1 and XBB.1.5 in sera of immunocompromised patients

Ist Teil von

• Med (New York, N.Y. : Online), 2023-10, Vol.4 (10), p.664-667

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Antibodies effective against the recent Omicron sublineages are missing. By taking advantage of a multi-centric prospective cohort of immunocompromised individuals treated for mild-to-moderate COVID-19, Bruel et al. show that administration of 500 mg of sotrovimab induces serum neutralization and antibody-dependent cellular cytotoxicity of BQ.1.1 and XBB.1.5. Therefore, sotrovimab may remain a therapeutic option against these variants. Antibodies effective against the recent Omicron sublineages are missing. By taking advantage of a multi-centric prospective cohort of immunocompromised individuals treated for mild-to-moderate COVID-19, Bruel et al. show that administration of 500 mg of sotrovimab induces serum neutralization and antibody-dependent cellular cytotoxicity of BQ.1.1 and XBB.1.5. Therefore, sotrovimab may remain a therapeutic option against these variants.