Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6590), p.eabj3986-eabj3986
2022
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Bacterial sensing via neuronal Nod2 regulates appetite and body temperature
- Ist Teil von
- Science (American Association for the Advancement of Science), 2022-04, Vol.376 (6590), p.eabj3986-eabj3986
- Ort / Verlag
- United States: The American Association for the Advancement of Science
- Erscheinungsjahr
- 2022
- Quelle
- Science Online_科学在线
- Beschreibungen/Notizen
- Gut bacteria influence brain functions and metabolism. We investigated whether this influence can be mediated by direct sensing of bacterial cell wall components by brain neurons. In mice, we found that bacterial peptidoglycan plays a major role in mediating gut-brain communication via the Nod2 receptor. Peptidoglycan-derived muropeptides reach the brain and alter the activity of a subset of brain neurons that express Nod2. Activation of Nod2 in hypothalamic inhibitory neurons is essential for proper appetite and body temperature control, primarily in females. This study identifies a microbe-sensing mechanism that regulates feeding behavior and host metabolism.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.abj3986Titel-ID: cdi_hal_primary_oai_HAL_pasteur_03700494v1
- Format
- –
- Schlagworte
- Ablation, Animals, Antibiotics, Appetite, Arcuate nucleus, Bacteria, Bacteria - genetics, Bacteria - metabolism, Body Temperature, Body weight gain, Brain, Cell walls, Circadian rhythms, Climate, Crosstalk, Digestive system, Digestive tract, Excitability, Fatty acids, Feeding, Feeding behavior, Females, Food, Food intake, Fragments, Homeostasis, Hybridization, Hypothalamus, Immune system, Intestinal microflora, Intestine, Life Sciences, Ligands, Metabolism, Metabolites, Mice, Microbiota, Microorganisms, Mucosa, Nesting, Nesting behavior, Nests, Neurobiology, Neuroimaging, Neuromodulation, Neurons, Neurons - metabolism, Neurons and Cognition, Nod2 Signaling Adaptor Protein - genetics, Nod2 Signaling Adaptor Protein - metabolism, Nuclei (cytology), Oral administration, Pathogenesis, Pattern recognition, Peptidoglycan - metabolism, Perturbation, Physiology, Temperature control, Thermoregulation, Viruses, γ-Aminobutyric acid