Details

Autor(en) / Beteiligte

• LY, Nary
• RECORDON-PINSON, Patricia
• PHOUNG, Viseth
• SREY, Chanthan
• LEANG SIM KRUY
• KOUM, Kanal
• CHHUM, Vannarith
• GLAZIOU, Philippe
• FLEURY, Herve J
• REYNES, Jean-Marc

Titel

Characterization of mutations in HIV type 1 isolates from 144 cambodian recently infected patients and pregnant women naive to antiretroviral drugs

Ist Teil von

• AIDS research and human retroviruses, 2005-11, Vol.21 (11), p.971-976

Ort / Verlag

Larchmont, NY: Liebert

Erscheinungsjahr

2005

Quelle

MEDLINE

Beschreibungen/Notizen

• A baseline study has been conducted to determine the polymorphism of reverse transcriptase, protease, and envelope genes of HIV-1 isolates from 146 antiretroviral drug-naive Cambodian patients including 22 seroconverters and 124 pregnant women having been diagnosed HIV positive for less than 1 year. Amplification of at least one gene was successful for 144 isolates. All three genes were obtained for 136 isolates. Subtyping showed that CRF01_AE was predominant (130 cases). According to the ANRS September 2004 list, polymorphism substitutions (>50% versus the subtype B consensus) of CRF01_AE at drug resistance positions were observed only in protease: I13V (81%), E35D (87%), M36I (100%), R41K (96%), and H69K (100%). Two strains bore one major resistance mutation to PIs: M46I and N88D. Five other strains carried drug resistance mutations to RTIs: K70R (one strain), V75M (three strains), and K101E (one strain). Of the isolates 4.9% had drug resistance mutations to antiretroviral drugs.