Details

Autor(en) / Beteiligte

• Lari, N.
• Rindi, L.
• Cristofani, R.
• Rastogi, N.
• Tortoli, E.
• Garzelli, C.

Titel

Association of Mycobacterium tuberculosis complex isolates of BOVIS and Central Asian (CAS) genotypic lineages with extrapulmonary disease

Ist Teil von

• Clinical microbiology and infection, 2009-06, Vol.15 (6), p.538-543

Ort / Verlag

Oxford, UK: Elsevier Ltd

Erscheinungsjahr

2009

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The association between isolate genotype, defined as in the international spoligotype database SpolDB4, and extrapulmonary tuberculosis was determined among 1009 patients in a population-based, 4-year survey performed in Tuscany, Italy. Extrapulmonary disease occurred in 24.2% of patients. A statistically significant association with extrapulmonary disease was found for the BOVIS (adjusted OR 3.2; 95% CI 1.2–8.1) and for the Central Asian (CAS) lineages (adjusted OR 2.3; 95% CI 1.0–5.1). These findings support the view that Mycobacterium tuberculosis strains within individual genotypic lineages might have evolved unique pathogenic characteristics that are capable of influencing the clinical outcome of the infection.