Details

Autor(en) / Beteiligte

• Perret, P.
• Bacot, S.
• Gèze, A.
• Gentil Dit Maurin, A.
• Debiossat, M.
• Soubies, A.
• Blanc-Marquis, V.
• Choisnard, L.
• Boutonnat, J.
• Ghezzi, C.
• Putaux, J.L.
• Lancelon-Pin, C.
• Riou, L.M.
• Wouessidjewe, D.

Titel

Biodistribution and preliminary toxicity studies of nanoparticles made of Biotransesterified β–cyclodextrins and PEGylated phospholipids

Ist Teil von

• Materials Science & Engineering C, 2018-04, Vol.85, p.7-17

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2018

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The modification of β-cyclodextrins (βCDs) by grafting alkyl chains on the primary and/or secondary face yields derivatives (βCD-C10) able to self-organize under nanoprecipitating conditions into nanoparticles (βCD-C10-NP) potentially useful for drug delivery. The co-nanoprecipitation of βCD-C10 with polyethylene glycol (PEG) chains yields PEGylated NPs (βCD-C10-PEG-NP) with potentially improved stealthiness. The objectives of the present study were to characterize the in vivo biodistribution of βCD-C10-PEG-NP with PEG chain length of 2000 and 5000Da using nuclear imaging, and to preliminarily evaluate the in vivo acute and extended acute toxicity of the most suitable system. The in vivo and ex vivo biodistribution features of naked and decorated nanoparticles were investigated over time following intravenous injection of 125I-radiolabeled nanoparticles to mice. The potential toxicity of PEGylated βCD-C10 nanosuspensions was evaluated in a preliminary in vivo toxicity study involving blood assays and tissue histology following repeated intraperitoneal injections of nanoparticles to healthy mice. The results indicated that βCD-C10-PEG5000-NP presented increased stealthiness with decreased in vivo elimination and increased blood kinetics without inducing blood, kidney, spleen, and liver acute and extended acute toxicity. βCD-C10-PEG5000-NPs are stealth and safe systems with potential for drug delivery. •β-Cyclodextrin-based nanoparticles (βCD-C10-PEG-NP) were synthetized and PEGylated.•βCD-C10-PEG-NP radiolabeling allowed the evaluation of their in vivo behavior.•Increasing PEG chain length resulted in increased βCD-C10-PEG-NP stealthiness.•βCD-C10-PEG5000-NP in vivo injection did not cause acute & extended acute toxicity.•βCD-C10-PEG5000-NPs are stealth and safe systems with potential for drug delivery.