Details

Autor(en) / Beteiligte

• Buchtová, N.
• D’Orlando, A.
• Judeinstein, P.
• Chauvet, O.
• Weiss, P.
• Le Bideau, J.

Titel

Water dynamics in silanized hydroxypropyl methylcellulose based hydrogels designed for tissue engineering

Ist Teil von

• Carbohydrate polymers, 2018-12, Vol.202, p.404-408

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Silanized hydroxypropyl methylcellulose based hydrogels were developed for cartilage and intervertebral disc tissue engineering. Herein, study of dynamics of confined water showed two different populations, identified as hydration and bulk-like water. The diffusion coefficient showed that bulk-like water diffuses over distances ∼10 μm without being affected by the hydrogel matrix. Addition of silica nanofibers leads to improved mechanical properties and enhanced diffusion coefficient. Good diffusion within hydrogels is essential for the application.