Immunobiology (1979), 2015-10, Vol.220 (10), p.1161-1169
2015
Details
- Autor(en) / Beteiligte
- Titel
- Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells
- Ist Teil von
- Immunobiology (1979), 2015-10, Vol.220 (10), p.1161-1169
- Ort / Verlag
- Netherlands: Elsevier GmbH
- Erscheinungsjahr
- 2015
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Lactate & SCFAs regulate proinflammatory activation of epithelial and myeloid cells. • Butyrate/propionate are effective at lower concentrations than lactate/acetate. • Lactate & SCFAs are immunomodulatory at intestinal physiological concentrations. • Modulatory activity of SCFAs and lactate are not related to Gi signaling. • These molecules could be useful in gastrointestinal inflammatory situations.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0171-2985eISSN: 1878-3279DOI: 10.1016/j.imbio.2015.06.004Titel-ID: cdi_hal_primary_oai_HAL_inserm_01182910v1
- Format
- –
- Schlagworte
- Advanced Basic Science, Allergy and Immunology, Animals, Bacteria - immunology, Caco-2 Cells, CD40 Antigens - immunology, Down-Regulation - immunology, Epithelial Cells - immunology, Fatty Acids - immunology, Female, Humans, Immunology, Immunomodulation, Inflammation, Innate immunity, Intestinal Mucosa - immunology, Intestinal Mucosa - microbiology, Lactate, Lactic Acid - immunology, Life Sciences, Mice, Myeloid Cells - immunology, Short chain fatty acids, Toll-Like Receptor 4 - immunology, Toll-Like Receptor 5 - immunology