The New England journal of medicine, 2011-07, Vol.365 (1), p.44-53
2011
Details
- Autor(en) / Beteiligte
- Titel
- A Hemodynamic Study of Pulmonary Hypertension in Sickle Cell Disease
- Ist Teil von
- The New England journal of medicine, 2011-07, Vol.365 (1), p.44-53
- Ort / Verlag
- Waltham, MA: Massachusetts Medical Society
- Erscheinungsjahr
- 2011
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Patients with sickle cell disease underwent ECG with assessment of tricuspid valve regurgitant jet velocity (TRJV) to screen for pulmonary hypertension, followed by right heart catheterization if the TRJV was 2.5 m per second or more. Prevalence was 27% on the basis of ECG criteria but only 6% on the basis of catheterization. In several studies, pulmonary hypertension, particularly pulmonary arterial hypertension, has been reported as a frequent complication of sickle cell disease. 1 – 4 Pulmonary arterial hypertension is characterized by the presence of precapillary pulmonary hypertension in the absence of left-sided heart disease, lung disease, or chronic thromboembolism. On histopathological analysis, pulmonary arterial hypertension is characterized by the proliferation of medial smooth-muscle cells and endothelial cells in the small pulmonary arteries. 5 Pulmonary arterial hypertension may be idiopathic, heritable, or associated with other disorders, such as connective tissue diseases and congenital heart disease. 6 In the updated classification of pulmonary hypertension, sickle cell disease appears . . .
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-4793eISSN: 1533-4406DOI: 10.1056/NEJMoa1005565Titel-ID: cdi_hal_primary_oai_HAL_inserm_00609555v1
- Format
- –
- Schlagworte
- Adult, Anemia, Sickle Cell, Anemia, Sickle Cell - complications, Anemias. Hemoglobinopathies, Biochemistry, Molecular Biology, Biological and medical sciences, Blood pressure, Brain natriuretic peptide, Cardiac catheterization, Cardiac Catheterization - adverse effects, Cardiovascular disease, Care and treatment, Catheterization, Causes of, Diagnosis, Diseases of red blood cells, Distribution, Doppler effect, Echocardiography, Echocardiography, Doppler, Female, General aspects, Health aspects, Health risk assessment, Heart, Heart Catheterization, Hematologic and hematopoietic diseases, Hemodynamics, Humans, Hypertension, Hypertension, Pulmonary, Hypertension, Pulmonary - diagnosis, Hypertension, Pulmonary - epidemiology, Hypertension, Pulmonary - etiology, Hypertension, Pulmonary - physiopathology, Intubation, Life Sciences, Liver diseases, Lung diseases, Male, Medical sciences, Pneumology, Prevalence, Prospective Studies, Pulmonary arteries, Pulmonary hypertension, Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases, Rheumatic heart disease, Sickle cell anemia, Sickle cell disease, Velocity