Science (American Association for the Advancement of Science), 2006-12, Vol.314 (5806), p.1788-1792
2006
Details
- Autor(en) / Beteiligte
- Titel
- Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery
- Ist Teil von
- Science (American Association for the Advancement of Science), 2006-12, Vol.314 (5806), p.1788-1792
- Ort / Verlag
- Washington, DC: American Association for the Advancement of Science
- Erscheinungsjahr
- 2006
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- We report a signaling mechanism in rats between mother and fetus aimed at preparing fetal neurons for delivery. In immature neurons, γ-aminobutyric acid (GABA) is the primary excitatory neurotransmitter. We found that, shortly before delivery, there is a transient reduction in the intracellular chloride concentration and an excitatory-to-inhibitory switch of GABA actions. These events were triggered by oxytocin, an essential maternal hormone for labor. In vivo administration of an oxytocin receptor antagonist before delivery prevented the switch of GABA actions in fetal neurons and aggravated the severity of anoxic episodes. Thus, maternal oxytocin inhibits fetal neurons and increases their resistance to insults during delivery.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.1133212Titel-ID: cdi_hal_primary_oai_HAL_inserm_00483930v1
- Format
- –
- Schlagworte
- Action Potentials, Animals, Animals, Newborn, Benzamides, Benzamides - pharmacology, Biological and medical sciences, Brain, Cellular Biology, Childbirth & labor, Chlorides, Chlorides - metabolism, Female, Fetal Hypoxia, Fetal Hypoxia - physiopathology, Fetus, Fetus - physiology, Fetuses, Fundamental and applied biological sciences. Psychology, GABA antagonists, GABA-A Receptor Agonists, GABA-A Receptor Antagonists, gamma-Aminobutyric Acid, gamma-Aminobutyric Acid - physiology, Hippocampus, Hippocampus - cytology, Hippocampus - embryology, Hippocampus - physiology, Hormone metabolism and regulation, Hormones, In Vitro Techniques, Indoles, Indoles - pharmacology, Life Sciences, Maternal-Fetal Exchange, Neural Inhibition, Neurons, Neurons - physiology, Neuroscience, Neurotransmitters, Oxytocin, Oxytocin - pharmacology, Oxytocin - physiology, Oxytocin receptors, Parturition, Patch-Clamp Techniques, Pregnancy, Pregnancy. Parturition. Lactation, Pyramidal cells, Rats, Rats, Wistar, Receptors, GABA-A, Receptors, GABA-A - physiology, Receptors, Oxytocin, Receptors, Oxytocin - antagonists & inhibitors, Rodents, Signal Transduction, Sodium Potassium Chloride Symporter Inhibitors, Sodium-Potassium-Chloride Symporters, Sodium-Potassium-Chloride Symporters - metabolism, Solute Carrier Family 12, Member 2, Vasotocin, Vasotocin - analogs & derivatives, Vasotocin - pharmacology, Vertebrates: reproduction