Details

Autor(en) / Beteiligte

• Chaput, Oriane
• Solt, Derek
• Sukavaneshvar, Sivaprasad
• Fenouil, Nathalie
• Burg, Brian R.
• Pouletty, Philippe
• Haulon, Stephan
• Fabre, Dominique

Titel

In-vitro Assessments of Clot Elicitation by Thrombogenic Fibers vs. Embolization Coils

Ist Teil von

• ASAIO journal (1992), 2022-10, Vol.68 (10), p.1256-1262

Ort / Verlag

Lippincott, Williams & Wilkins

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Late and persistent type II endoleaks (EL2) following Endovascular Aneurysm Repair (EVAR) have been recognized as an independent and significant risk factor for aneurysm sac growth and secondary procedures. Solutions are available for treatment, with varying success rates; preventive perioperative sac embolization with coils appears safe and effective. The objective of this study is to compare whole blood coagulation elicited by a textile stent-graft equipped with thrombogenic, patented “Kardiozis” fibers (PKF) to that elicited by embolization coils in an in vitro study. The approach is to establish an equivalence between PKF and coils in a static model, then to compare clot elicitation by both materials in a perfused model aneurysm chamber subjected to EL2. The weight of clot elicited during exposure to blood was the primary measurement. In the static model, PKF and coils were soaked in blood for up to 90 minutes ( N = 30) and elicited similar clotting. In the dynamic model, stent-grafts equipped with PKF or coils were exposed to blood flow inside an aneurysm model for up to 3h ( N = 5), with generally higher clot weights for stent-grafts with PKF (non-significant). Complete thrombosis of the aneurysm model was observed in one experimental series (positive control and stent-graft with PKF). A stent-graft with PKF elicits at least as much clot as embolization coils dispersed in an aneurysm model chamber under continuous blood flow. PKF positioned on the outer wall of stent-grafts could have a similar action as coiling of the aneurysm sac during the index EVAR.