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The hippocampus plays a critical role at encoding discontiguous events for subsequent declarative memory expression in mice
Hippocampus, 2007-01, Vol.17 (4), p.264-270
Mingaud, Frédérique
Le Moine, Catherine
Etchamendy, Nicole
Mormède, Cécile
Jaffard, Robert
Marighetto, Aline
2007
Details
Autor(en) / Beteiligte
Mingaud, Frédérique
Le Moine, Catherine
Etchamendy, Nicole
Mormède, Cécile
Jaffard, Robert
Marighetto, Aline
Titel
The hippocampus plays a critical role at encoding discontiguous events for subsequent declarative memory expression in mice
Ist Teil von
Hippocampus, 2007-01, Vol.17 (4), p.264-270
Ort / Verlag
Hoboken: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2007
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
The hypothesis that hippocampal activity at encoding is causally related to subsequent declarative memory expression is tested in the mouse, by using lidocaine inactivation of the hippocampus in combination with c‐fos neuroimaging analysis. We employed a two‐stage radial maze paradigm of spatial discrimination, which was previously shown to dissociate between declarative and nondeclarative expression of memory related to the same acquired material. In Stage 1 (encoding), mice learnt the constant location of food among a set of six arms (three baited, three unbaited) by being submitted repeatedly to discontiguous experiences with each arm separately (“go/no‐go” discrimination). In Stage 2 (test‐session), they are challenged with novel presentations of the arms, which are either combined into pairs of opposite valence (“two‐choice” discrimination), or opened all six together (“six‐choice” discrimination). Previous experiments have demonstrated that the “two‐choice” situation is a critical test for declarative memory while “six‐choice” discrimination may rely on procedural memory. We observed that (i) hippocampal activity measured by c‐fos mRNA expression was increased by “go/no‐go” learning, and this activation was blocked by pre‐training local infusions of lidocaine; (ii) when performed just before each session of Stage 1, such inactivation spared the acquisition of “go/no‐go” discrimination but produced, subsequently, a selective deficit in the “two‐choice” test (not in the “six‐choice” test). This study indicates that the hippocampus is “spontaneously” engaged in encoding processes necessary for long‐term storage of discontiguous experiences under a form enabling flexible declarative memory expression. © 2007 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 1050-9631
eISSN: 1098-1063
DOI: 10.1002/hipo.20262
Titel-ID: cdi_hal_primary_oai_HAL_hal_04514453v1
Format
–
Schlagworte
Analysis of Variance
,
Anesthetics, Local - pharmacology
,
Animals
,
Behavior, Animal
,
declarative/relational memory
,
Discrimination (Psychology) - drug effects
,
Discrimination (Psychology) - physiology
,
Gene Expression Regulation - drug effects
,
Gene Expression Regulation - physiology
,
Hippocampus - physiology
,
immediate early gene c-fos
,
In Situ Hybridization
,
Lidocaine - pharmacology
,
lidocaïne
,
Life Sciences
,
Male
,
Maze Learning - drug effects
,
Maze Learning - physiology
,
Memory - drug effects
,
Memory - physiology
,
Mice
,
Mice, Inbred C57BL
,
Neurons and Cognition
,
Proto-Oncogene Proteins c-fos - genetics
,
Proto-Oncogene Proteins c-fos - metabolism
,
radial maze
,
Spatial Behavior - drug effects
,
Spatial Behavior - physiology
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