Details

Autor(en) / Beteiligte

• Marchal, Stéphane
• Andriantsitohaina, Ramaroson
• Martinez, M. Carmen

Titel

Biotherapeutic approaches against cardio-metabolic dysfunctions based on extracellular vesicles

Ist Teil von

• Biochimica et biophysica acta. Molecular basis of disease, 2024-04, Vol.1870 (4), p.167095-167095, Article 167095

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2024

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Among the different pathways involved in the cell-to-cell communication, extracellular vesicles (EVs) are defined as key players in the transport of different signalling molecules, such as lipids, proteins, and RNA, from the originating cells to specific target cells. The biogenesis and composition of EVs are complex and confer them a unique ability to more effectively reach tissues and cells as compared to other types of synthetic carriers. Owing to these properties, EVs have been suggested as new therapeutic tools for personalized medicine. Since cardiometabolic diseases have reached pandemic proportions, new therapies are needed to be developed. In this context, EVs appear as promising therapeutic tools against cardiometabolic disorders associated with obesity and diabetes. This review focuses on the latest research on preclinical applications of EVs for cardiometabolic diseases, and draw primarily on our experience in this area. •Extracellular vesicles (EVs) are involved in the cell-to-cell communication.•EVs have been suggested as new therapeutic tools for personalized medicine.•EVs possess multiple properties that can act synergistically on damaged tissues.•EVs can contribute to the recovery of function of damaged tissue.