Details

Autor(en) / Beteiligte

• Dries, Eef
• Gilbert, Guillaume
• Roderick, H. Llewelyn
• Sipido, Karin R.

Titel

The ryanodine receptor microdomain in cardiomyocytes

Ist Teil von

• Cell calcium (Edinburgh), 2023-09, Vol.114, p.102769-102769, Article 102769

Ort / Verlag

Netherlands: Elsevier Ltd

Erscheinungsjahr

2023

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• •Ryanodine receptor (RyR) cluster morphology, subcellular localization, and associated signalling molecules define RyR microdomains within cardiomyocytes.•Disease-related structural remodelling affects local signalling and cluster morphology resulting in altered RyR function within microdomains.•Ongoing advancements in technology provide perspectives to further characterize and target dysfunctional RyRs within microdomains. The ryanodine receptor type 2 (RyR) is a key player in Ca2+ handling during excitation-contraction coupling. During each heartbeat, RyR channels are responsible for linking the action potential with the contractile machinery of the cardiomyocyte by releasing Ca2+ from the sarcoplasmic reticulum. RyR function is fine-tuned by associated signalling molecules, arrangement in clusters and subcellular localization. These parameters together define RyR function within microdomains and are subject to disease remodelling. This review describes the latest findings on RyR microdomain organization, the alterations with disease which result in increased subcellular heterogeneity and emergence of microdomains with enhanced arrhythmogenic potential, and presents novel technologies that guide future research to study and target RyR channels within specific microdomains. [Display omitted]