Details

Autor(en) / Beteiligte

• Bal, Antonin
• Brengel-Pesce, Karen
• Gaymard, Alexandre
• Quéromès, Grégory
• Guibert, Nicolas
• Frobert, Emilie
• Bouscambert, Maude
• Trabaud, Mary-Anne
• Allantaz-Frager, Florence
• Oriol, Guy
• Cheynet, Valérie
• d'Aubarede, Constance
• Massardier-Pilonchery, Amélie
• Buisson, Marlyse
• Lupo, Julien
• Pozzetto, Bruno
• Poignard, Pascal
• Lina, Bruno
• Fassier, Jean-Baptiste
• Morfin, Florence
• Trouillet-Assant, Sophie
• Adnot, Jerôme
• Alfaiate, Dulce
• Bergeret, Alain
• Boibieux, André
• Bonnet, Florent
• Brunel-Dalmas, Florence
• Caire, Eurydice
• Charbotel, Barbara
• Chiarello, Pierre
• Cotte, Laurent
• Durupt, François
• Escuret, Vanessa
• Fascia, Pascal
• Fontaine, Juliette
• Gaillot-Durand, Lucie
• Gillet, Myriam
• Godinot, Matthieu
• Gueyffier, François
• Josset, Laurence
• Lahousse, Matthieu
• Lozano, Hélène
• Makhloufi, Djamila
• Milon, Marie-Paule
• Moll, Frédéric
• Narbey, David
• Nazare, Julie-Anne
• Oria, Fatima
• Perry, Marielle
• Pitiot, Virginie
• Prudent, Mélanie
• Rabilloud, Muriel
• Samperiz, Audrey
• Schlienger, Isabelle
• Simon, Chantal
• Valette, Martine

Titel

Clinical and laboratory characteristics of symptomatic healthcare workers with suspected COVID-19: a prospective cohort study

Ist Teil von

• Scientific reports, 2021-07, Vol.11 (1)

Ort / Verlag

Nature Publishing Group

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• A comprehensive clinical and microbiological assessments of COVID-19 in front-line healthcare workers (HCWs) is needed. Between April 10th and May 28th, 2020, 319 HCWs with acute illness were reviewed. In addition to SARS-CoV-2 RT-PCR screening, a multiplex molecular panel was used for testing other respiratory pathogens. For SARS-CoV-2 positive HCWs, the normalized viral load, viral culture, and virus neutralization assays were performed weekly. For SARS-CoV-2 negative HCWs, SARS-CoV-2 serological testing was performed one month after inclusion. Among the 319 HCWs included, 67 (21.0%) were tested positive for SARS-CoV-2; 65/67 (97.0%) developed mild form of COVID-19. Other respiratory pathogens were found in 6/66 (9.1%) SARS-CoV-2 positive and 47/241 (19.5%) SARS-Cov-2 negative HCWs ( p = 0.07). The proportion of HCWs with a viral load > 5.0 log 10 cp/mL (Ct value < 25) was less than 15% at 8 days after symptom onset; 12% of HCWs were positive after 40 days (Ct > 37). More than 90% of cultivable virus had a viral load > 4.5 log 10 cp/mL (Ct < 26) and were collected within 10 days after symptom onset. Among negative HCWs, 6/190 (3.2%) seroconverted. Our data suggest that the determination of viral load can be used for appreciating the infectiousness of infected HCWs. These data could be helpful for facilitating their return to work.