Details

Autor(en) / Beteiligte

• Wu, Yin
• Levis, Brooke
• Daray, Federico M.
• Ioannidis, John P. A.
• Patten, Scott B.
• Cuijpers, Pim
• Ziegelstein, Roy C.
• Gilbody, Simon
• Fischer, Felix H.
• Fan, Suiqiong
• Sun, Ying
• He, Chen
• Krishnan, Ankur
• Neupane, Dipika
• Bhandari, Parash Mani
• Negeri, Zelalem
• Rice, Danielle B.
• Azar, Marleine
• Imran, Mahrukh
• Boruff, Jill T.
• McMillan, Dean
• Kloda, Lorie A.
• Markham, Sarah
• Henry, Melissa
• Ismail, Zahinoor
• Loiselle, Carmen G.
• Mitchell, Nicholas D.
• Al-Adawi, Samir
• Beck, Kevin R.
• Beraldi, Anna
• Bernstein, Charles N.
• Boye, Birgitte
• Büel-Drabe, Natalie
• Bunevicius, Adomas
• Can, Ceyhun
• Carter, Gregory
• Cheung, Gary
• Clover, Kerrie
• Costa-Requena, Gema
• Cukor, Daniel
• Downing, Marina
• Ferentinos, Panagiotis P.
• Flint, Alastair J.
• Gallagher, Pamela
• Gandy, Milena
• Grassi, Luigi
• Härter, Martin
• Hernando, Asuncion
• Jackson, Melinda L.
• Jenewein, Josef
• Jetté, Nathalie
• Julião, Miguel
• Kjærgaard, Marie
• Köhler, Sebastian
• Krishna, Lalit K. R.
• Lee, Yu
• Löbner, Margrit
• Loosman, Wim L.
• Love, Anthony W.
• Löwe, Bernd
• Malt, Ulrik F.
• Marrie, Ruth Ann
• Massardo, Loreto
• Matsuoka, Yutaka
• Misery, Laurent
• Nelson, Christian J.
• Ng, Chong Guan
• O'Donnell, Meaghan L.
• O'Rourke, Suzanne J.
• Pabst, Alexander
• Pulido, Federico
• Quinn, Terence J.
• Reme, Silje E.
• Reuter, Katrin
• Riedel-Heller, Steffi G.
• Rooney, Alasdair G.
• Schellekens, Melanie P. J.
• Scherer, Martin
• Schwarzbold, Marcelo L.
• Sharpe, Louise
• Sharpe, Michael
• Simard, Sébastien
• Singer, Susanne
• Stafford, Lesley
• Stone, Jon
• Strobel, Natalie A.
• Sultan, Serge
• Teixeira, Antonio L.
• Tiringer, Istvan
• Turner, Alyna
• Walker, Jane
• Walterfang, Mark
• Wang, Liang-Jen
• Weyerer, Siegfried B.
• White, Jennifer
• Wiese, Birgitt
• Williams, Lana J.
• Wong, Lai-Yi
• Benedetti, Andrea
• Thombs, Brett D.
• Suhr, Julie A

Titel

Comparison of the Accuracy of the 7-Item HADS Depression Subscale and 14-Item Total HADS for Screening for Major Depression: A Systematic Review and Individual Participant Data Meta-Analysis

Ist Teil von

• Psychological assessment, 2023-02, Vol.35 (2), p.95-114

Ort / Verlag

United States: American Psychological Association

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• The seven-item Hospital Anxiety and Depression Scale Depression subscale (HADS-D) and the total score of the 14-item HADS (HADS-T) are both used for major depression screening. Compared to the HADS-D, the HADS-T includes anxiety items and requires more time to complete. We compared the screening accuracy of the HADS-D and HADS-T for major depression detection. We conducted an individual participant data meta-analysis and fit bivariate random effects models to assess diagnostic accuracy among participants with both HADS-D and HADS-T scores. We identified optimal cutoffs, estimated sensitivity and specificity with 95% confidence intervals, and compared screening accuracy across paired cutoffs via two-stage and individual-level models. We used a 0.05 equivalence margin to assess equivalency in sensitivity and specificity. 20,700 participants (2,285 major depression cases) from 98 studies were included. Cutoffs of ≥7 for the HADS-D (sensitivity 0.79 [0.75, 0.83], specificity 0.78 [0.75, 0.80]) and ≥15 for the HADS-T (sensitivity 0.79 [0.76, 0.82], specificity 0.81 [0.78, 0.83]) minimized the distance to the top-left corner of the receiver operating characteristic curve. Across all sets of paired cutoffs evaluated, differences of sensitivity between HADS-T and HADS-D ranged from −0.05 to 0.01 (0.00 at paired optimal cutoffs), and differences of specificity were within 0.03 for all cutoffs (0.02-0.03). The pattern was similar among outpatients, although the HADS-T was slightly (not nonequivalently) more specific among inpatients. The accuracy of HADS-T was equivalent to the HADS-D for detecting major depression. In most settings, the shorter HADS-D would be preferred. Public Significance Statement The present study suggests that the accuracy of 14-item Hospital Anxiety and Depression Scale (HADS-D) and the seven-item HADS Depression subscale (HADS-D) are equivalent for detecting major depression. Using the seven-item HADS-D for depression screening instead of the full 14-item HADS-T has minimal influence on performance of the measure but would reduce patient and participant burden in most clinical and research settings.