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Charting Disease Trajectories from Isolated REM Sleep Behavior Disorder to Parkinson's Disease
Movement disorders, 2024-01, Vol.39 (1), p.64-75
Di Folco, Cécile
Couronné, Raphaël
Arnulf, Isabelle
Mangone, Graziella
Leu‐Semenescu, Smaranda
Dodet, Pauline
Vidailhet, Marie
Corvol, Jean‐Christophe
Lehéricy, Stéphane
Durrleman, Stanley
2024
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Di Folco, Cécile
Couronné, Raphaël
Arnulf, Isabelle
Mangone, Graziella
Leu‐Semenescu, Smaranda
Dodet, Pauline
Vidailhet, Marie
Corvol, Jean‐Christophe
Lehéricy, Stéphane
Durrleman, Stanley
Titel
Charting Disease Trajectories from Isolated REM Sleep Behavior Disorder to Parkinson's Disease
Ist Teil von
Movement disorders, 2024-01, Vol.39 (1), p.64-75
Ort / Verlag
Hoboken, USA: John Wiley & Sons, Inc
Erscheinungsjahr
2024
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
Background Clinical presentation and progression dynamics are variable in patients with Parkinson's disease (PD). Disease course mapping is an innovative disease modelling technique that summarizes the range of possible disease trajectories and estimates dimensions related to onset, sequence, and speed of progression of disease markers. Objective To propose a disease course map for PD and investigate progression profiles in patients with or without rapid eye movement sleep behavioral disorders (RBD). Methods Data of 919 PD patients and 88 isolated RBD patients from three independent longitudinal cohorts were analyzed (follow‐up duration = 5.1; 95% confidence interval, 1.1–8.1] years). Disease course map was estimated by using eight clinical markers (motor and non‐motor symptoms) and four imaging markers (dopaminergic denervation). Results PD course map showed that the first changes occurred in the contralateral putamen 13 years before diagnosis, followed by changes in motor symptoms, dysautonomia, sleep—all before diagnosis—and finally cognitive decline at the time of diagnosis. The model showed earlier disease onset, earlier non‐motor and later motor symptoms, more rapid progression of cognitive decline in PD patients with RBD than PD patients without RBD. This pattern was even more pronounced in patients with isolated RBD with early changes in sleep, followed by cognition and non‐motor symptoms and later changes in motor symptoms. Conclusions Our findings are consistent with the presence of distinct patterns of progression between patients with and without RBD. Understanding heterogeneity of PD progression is key to decipher the underlying pathophysiology and select homogeneous subgroups of patients for precision medicine. © 2023 International Parkinson and Movement Disorder Society.
Sprache
Englisch
Identifikatoren
ISSN: 0885-3185
eISSN: 1531-8257
DOI: 10.1002/mds.29662
Titel-ID: cdi_hal_primary_oai_HAL_hal_04319442v1
Format
–
Schlagworte
Behavior disorders
,
Bioengineering
,
Bioinformatics
,
Cognition
,
Cognitive ability
,
Cognitive Dysfunction
,
Cognitive science
,
Computer Science
,
Denervation
,
Diagnosis
,
disease modelling
,
Dopamine receptors
,
Dysautonomia
,
Human health and pathology
,
Humans
,
Imaging
,
Life Sciences
,
longitudinal data
,
Modeling and Simulation
,
Movement disorders
,
Neurodegenerative diseases
,
Neuroscience
,
Parkinson Disease
,
Parkinson's disease
,
Polysomnography
,
Precision medicine
,
Putamen
,
REM sleep
,
REM sleep behavior disorder
,
REM Sleep Behavior Disorder - diagnosis
,
Sleep disorders
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