Details

Autor(en) / Beteiligte

• Ma, Yandong
• Zhang, Zhihua
• Sun, Fan
• Mesdom, Pierre
• Ji, Xin
• Burckel, Pierre
• Gasser, Gilles
• Li, Min-Hui

Titel

Red-Light-Responsive Polypeptoid Nanoassemblies Containing a Ruthenium(II) Polypyridyl Complex with Synergistically Enhanced Drug Release and ROS Generation for Anticancer Phototherapy

Ist Teil von

• Biomacromolecules, 2023-12, Vol.24 (12), p.5940-5950

Ort / Verlag

United States: American Chemical Society

Erscheinungsjahr

2023

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Polymer micelles/vesicles made of a red-light-responsive Ru­(II)-containing block copolymer (PolyRu) are elaborated as a model system for anticancer phototherapy. PolyRu is composed of PEG and a hydrophobic polypeptoid bearing thioether side chains, 40% of which are coordinated with [Ru­(2,2′:6′,2″-terpyridine)­(2,2′-biquinoline)]­(PF6)2 via the Ru–S bond, resulting in a 67 wt % Ru complex loading capacity. Red-light illumination induces the photocleavage of the Ru–S bond and produces [Ru­(2,2′:6′,2″-terpyridine)­(2,2′-biquinoline)­(H2O)]­(PF6)2. Meanwhile, ROS are generated under the photosensitization of the Ru complex and oxidize hydrophobic thioether to hydrophilic sulfoxide, causing the disruption of micelles/vesicles. During the disruption, ROS generation and Ru complex release are synergistically enhanced. PolyRu micelles/vesicles are taken up by cancer cells while they exhibit very low cytotoxicity in the dark. In contrast, they show much higher cytotoxicity under red-light irradiation. PolyRu micelles/vesicles are promising nanoassembly prototypes that protect metallodrugs in the dark but exhibit light-activated anticancer effects with spatiotemporal control for photoactivated chemotherapy and photodynamic therapy.