Médecine et maladies infectieuses, 2020-10, Vol.50 (7), p.611-616
- Farfour, E.
- Degand, N.
- Riverain, E.
- Fihman, V.
- Le Brun, C.
- Péan de Ponfilly, G.
- Muggeo, A.
- Jousset, A.
- Piau, C.
- Lesprit, P.
- Chatelain, N.
- Dortet, L.
- Poisson, A.
- Guillard, T.
- Limelette, A.
- Mizrahi, A.
- Le Monnier, A.
- Fournier, D.
- Potron, A.
- Morand, P.
- Janvier, F.
- Otto, M.-P.
- Woerther, P.-L.
- Decousser, J.-W.
- Corvec, S.
- Plouzeau-Jayle, C.
- Broutin, L.
- Yin, N.
- Héry-Arnaud, G.
- Beauruelle, C.
- Grillon, A.
- Lecuru, M.
- Bille, E.
- Godreuil, S.
- Jean Pierre, H.
- Amara, M.
- Henry, A.
- Zahar, J.-R.
- Carbonelle, E.
- Jaureguy, F.
- Lomont, A.
- Isnard, C.
- Cattoir, V.
- Canis, F.
- Diedrich, T.
- Flevin, E.
- Merens, A.
- Jacquier, H.
- Gyde, E.
2020
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Farfour, E.
- Degand, N.
- Riverain, E.
- Fihman, V.
- Le Brun, C.
- Péan de Ponfilly, G.
- Muggeo, A.
- Jousset, A.
- Piau, C.
- Lesprit, P.
- Chatelain, N.
- Dortet, L.
- Poisson, A.
- Guillard, T.
- Limelette, A.
- Mizrahi, A.
- Le Monnier, A.
- Fournier, D.
- Potron, A.
- Morand, P.
- Janvier, F.
- Otto, M.-P.
- Woerther, P.-L.
- Decousser, J.-W.
- Corvec, S.
- Plouzeau-Jayle, C.
- Broutin, L.
- Yin, N.
- Héry-Arnaud, G.
- Beauruelle, C.
- Grillon, A.
- Lecuru, M.
- Bille, E.
- Godreuil, S.
- Jean Pierre, H.
- Amara, M.
- Henry, A.
- Zahar, J.-R.
- Carbonelle, E.
- Jaureguy, F.
- Lomont, A.
- Isnard, C.
- Cattoir, V.
- Canis, F.
- Diedrich, T.
- Flevin, E.
- Merens, A.
- Jacquier, H.
- Gyde, E.
- Titel
- Fosfomycin, from susceptibility to resistance: Impact of the new guidelines on breakpoints
- Ist Teil von
- Médecine et maladies infectieuses, 2020-10, Vol.50 (7), p.611-616
- Ort / Verlag
- Elsevier Masson
- Erscheinungsjahr
- 2020
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- The fosfomycin breakpoint using the disc diffusion method (DDM) changed in the 2019 CA-SFM/EUCAST guidelines v2 (24mm versus 19mm). We assessed its impact on categorization of Enterobacterales recovered from urine samples in emergency departments. A total of 7749 and 2348 strains were tested using the DDM and the broth microdilution method (BMD), respectively. The DDM with the 19-mm breakpoint was in accordance with the BMD. Using the 24-mm breakpoint, the overall rate of fosfomycin resistance in Enterobacterales increased by three-fold (5.6% vs 18.1%, P<0.01) and reached 2.8% and 86.5% in E. coli and K. pneumoniae, respectively. French guidelines for the management of community-acquired UTI remain appropriate. The accuracy of the methods for routine fosfomycin susceptibility testing should be assessed. The role of fosfomycin in the treatment of documented CA-UTI due to Enterobacterales other than E. coli should be evaluated considering its rate of resistance and recent data reporting low accuracy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0399-077XDOI: 10.1016/j.medmal.2020.07.003Titel-ID: cdi_hal_primary_oai_HAL_hal_04226097v1