Details

Autor(en) / Beteiligte

• Mailles, Alexandra
• Stahl, Jean Paul
• Tattevin, Pierre
• Argemi, Xavier
• Baille, Guillaume
• Baldolli, Aurélie
• Benghanem, Sarah
• Bertrand, Kevin
• Biberon, Julien
• Biron, Charlotte
• Fourcade, Geneviève Blanchet
• Blot, Mathieu
• Bothelo-Nevers, Elisabeth
• Boutoille, David
• Brasme, Hélène
• Bruel, Cédric
• Buzele, Rodolphe
• Canet, Emmanuel
• Canoui, Etienne
• Casenave, Philippe
• Castan, Bernard
• Cazanave, Charles
• Cazorla, Céline
• Chavanet, Pascal
• Chirouze, Catherine
• Chroboczek, Tomasz
• De Broucker, Thomas
• De La Blanchardiere, Arnaud
• De Montmollin, Etienne
• Denes, Eric
• Deschanvres, Colin
• Dinh, Aurélien
• Epaulard, Olivier
• Fillatre, Pierre
• Fraisse, Thibaut
• Gaborit, Benjamin
• Gagneux-Brunon, Amandine
• Gaillard, Nicolas
• Godement, Mathieu
• Goehringer, François
• Goubin, Pascale
• Gravier, Simon
• Gueit, Isabelle
• Guimard, Thomas
• Henry, Carole
• Hentzien, Maxime
• Jaquet, Pierre
• Jurici, Snejana
• Kerneis, Solen
• Le Bras, Morgane
• Le Marechal, Marion
• Le Moal, Gwenael
• Le Turnier, Paul
• Lecompte, Anne-Sophie
• Lescure, François-Xavier
• Lesieur, Olivier
• Mahieu, Rafael
• Makinson, Alain
• Marc, Guillaume
• Maria, Alexandre
• Marin, Nathalie
• Martin-Blondel, Guillaume
• Martinot, Martin
• Mas, Alexandre
• Mateu, Philippe
• Matt, Morgan
• Maulin, Laurence
• Pachart, Anne
• Pansu, Nathalie
• Patrat-Delon, Solene
• Pavese, Patricia
• Pelerin, Hélène
• Pelonde-Erimée, Véronique
• Pierre, Isabelle
• Piet, Emilie
• Psimaras, Dimitri
• Puges, Mathilde
• Reignier, Jean
• Istin, Mathilde Reveillon
• Rheims, Sylvain
• Richard-Mornas, Aurélie
• Roubeau, Vincent
• Ruch, Yvon
• Runge, Isabelle
• Sonneville, Romain
• Tyvaert, Louise
• Vareil, Marc-Olivier
• Vidal-Roux, Magali
• Vitrat, Virginie
• Wille, Heidi
• Almoyna-Martinez, Laurent
• Bruneel, Fabrice
• Roblot, France
• Stahl, Jean-Paul

Titel

Characteristics, management, and outcomes of patients with infectious encephalitis requiring intensive care: A prospective multicentre observational study

Ist Teil von

• Journal of critical care, 2023-10, Vol.77, p.154300-154300, Article 154300

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2023

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Infectious encephalitis (IE) is a severe disease which requires intensive care unit (ICU) admission in up to 50% of cases. We aimed to describe characteristics, management and outcomes of IE patients who required ICU admission. Ancillary study focusing on patients with ICU admission within the ENCEIF cohort, a French prospective observational multicentre study. The primary criteria for outcome was the functional status at hospital discharge, categorized using the Glasgow outcome scale (GOS). Logistic regression model was used to identify risk factors for poor outcome, defined as a GOS ≤ 3. We enrolled 198 ICU patients with IE. HSV was the primary cause (n = 72, 36% of all IE, 53% of IE with microbiological documentation). Fifty-two patients (26%) had poor outcome at hospital discharge, including 22 deaths (11%). Immunodeficiency, supratentorial focal signs on admission, lower cerebrospinal fluid (CSF) white cells count (<75/mm3), abnormal brain imaging, and time from symptoms onset to acyclovir start >2 days were independent predictors of poor outcome. HSV is the primary cause of IE requiring ICU admission. IE patients admitted in ICU have a poor prognosis with 11% of in-hospital mortality and 15% of severe disabilities in survivors at discharge. •HSV is the primary cause of encephalitis requiring ICU admission•Poor functional outcome at hospital discharge was found in 26% of cases.•Time from symptom onset to acyclovir start >2 days was associated with poor outcome•Lower CSF white cells count was an independent predictor of poor outcome