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Association of gut‐specific non‐inflammatory T lymphocytes with chronic anorexia nervosa and constitutional thinness
Ist Teil von
European eating disorders review, 2023-01, Vol.31 (1), p.76-86
Ort / Verlag
England: John Wiley and Sons, Limited
Erscheinungsjahr
2023
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Objective
Previous studies of AN showed low‐grade inflammation. Are low‐grade inflammation and circulating lymphocytes associated with chronic conditions?
Method
Peripheric blood cytokines were measured using Luminex™ technology in a chronic AN cohort (mean = 67.42 months), compared to Constitutional Thinness (CT), Constitutional Obesity (CO), and Healthy Controls (HC). Secondarily a prospective cohort of chronic AN (mean = 54.11 months) was recruited to compare the functional lymphocyte profile in blood by flow cytometry to CT and HC.
Results
In the AN group, most cytokine concentrations were lower than in CT and HC groups. The IL‐23 (98.02 pg/ml) was elevated related to HC and CO, and the IL‐10 (4.178 pg/ml) was elevated versus CO. In the CT group, IL‐9 (0.06216 pg/ml) was elevated compared to AN. The AN group had high Treg (9.259% of CD4+) and CD8+Integrinβ7+ (9.552% of CD3+) versus HC for lymphocyte populations. In CT group, elevated Treg (9.7% of CD4+) elevated percentage of CD4+CCR9+ (5.867% of CD3+) and CD8+Integrinβ7+ (10.21% of CD3+) were found versus HC.
Conclusions
The chronic state of AN and CT is surprisingly non‐inflammatory with elevated Treg cells. These results suggest that maintaining a dysregulated response to intestinal antigens may contribute to maintaining AN.
Key points
Constitutional thinness and chronic anorexia nervosa show that thinness is associated with a close immunological pattern
Cytokine profile of constitutional thinness and chronic anorexia nervosa is not pro‐inflammatory
Circulating lymphocytes profile in constitutional thinness and anorexia nervosa is not pro‐inflammatory