Details

Autor(en) / Beteiligte

• Espindola, Reinaldo
• Vella, Venanzio
• Benito, Natividad
• Mur, Isabel
• Tedeschi, Sara
• Rossi, Nicolò
• Hendriks, Johannes G.E.
• Sorlí, Luisa
• Murillo, Oscar
• Scarborough, Mathew
• Scarborough, Claire
• Kluytmans, Jan
• Ferrari, Mateo Carlo
• Pletz, Mathias W.
• Mcnamara, Iain
• Escudero-Sanchez, Rosa
• Arvieux, Cedric
• Batailler, Cecile
• Dauchy, Frédéric-Antoine
• Liu, Wai-Yan
• Lora-Tamayo, Jaime
• Praena, Julia
• Ustianowski, Andrew
• Cinconze, Elisa
• Pellegrini, Michele
• Bagnoli, Fabio
• Rodríguez-Baño, Jesús
• Del Toro, Maria Dolores
• Cuperus, Nienke
• Manfré, Giuseppe
• Zamparini, Eleonora
• Verhagen, Stéphanie
• Horcajada, Juan P.
• Junyent, Joan Gómez
• Alier, Albert
• Soldevila, Laura
• van Rijen, Miranda
• Romme, Jannie
• Ankert, Juliane
• Whitehouse, Celia
• Jones, Adrian
• Cobo, Javier
• Moreno, Javier
• Meheut, Anne
• Gledel, Claire
• Perreau, Pauline
• van Wensen, Remco J.A.
• Lindergard, Gabriella
• Peñas, Cecilia
• Albarracín, Ana Conde
• Palomino, Julián
• Brun, Francisco
• Sánchez, Santiago

Titel

Preoperative and perioperative risk factors, and risk score development for prosthetic joint infection due to Staphylococcus aureus: A multinational matched case-control study

Ist Teil von

• Clinical microbiology and infection, 2022-10, Vol.28 (10), p.1359-1366

Ort / Verlag

England: Elsevier Ltd

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• We aim to identify the preoperative and perioperative risk factors associated with post-surgical Staphylococcus aureus prosthetic joint infections (PJI), and to develop and validate risk-scoring systems, to allow a better identification of high-risk patients for more efficient targeted interventions. We performed a multicenter matched case-control study of patients who underwent a primary hip and knee arthroplasty from 2014 to 2016. Two multivariable models by logistic regression were performed, one for the preoperative and one for perioperative variables; also, predictive scores were developed and validated in an external cohort. In total, 130 cases and 386 controls were included. The variables independently associated with S. aureus-PJI in the preoperative period were (adjusted OR; 95% CI): BMI >30 kg/m2 (3.0; 1.9-4.8), resident in a long-term care facility (2.8; 1.05-7.5), fracture as reason for arthroplasty (2.7; 1.4-5.03), skin disorders (2.5; 0.9-7.04), previous surgery in the index joint (2.4; 1.3-4.4), male sex (1.9; 1.2-2.9) and ASA score 3-4 (1.8; 1.2-2.9). The AUROC curve was 0.73 (95% CI 0.68-0.78). In perioperative model, the risk factors were the previous ones plus surgical antibiotic prophylaxis administered out of the first 60 minutes before incision (5.9; 2.1-16.2), wound drainage for >72h after arthroplasty (4.5; 1.9-19.4) and use of metal bearing material vs. ceramic (1.9; 1.1-3.3). The AUROC curve was 0.78 (95% CI 0.72-0.83). The predictive scores developed were validated in the external cohort. Predictive scores for S. aureus-PJI were developed and validated; this information would be useful for implementation of specific preventive measures.