Details

Autor(en) / Beteiligte

• Geoffron, S.
• Lier, A.
• de Kermadec, E.
• Sermondade, N.
• Varinot, J.
• Thomassin-Naggara, I.
• Bendifallah, S.
• Daraï, E.
• Chabbert-Buffet, N.
• Kolanska, K.

Titel

Fertility preservation in women with malignant and borderline ovarian tumors: Experience of the French ESGO-certified center and pregnancy-associated cancer network (CALG)

Ist Teil von

• Gynecologic oncology, 2021-06, Vol.161 (3), p.817-824

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• To describe strategy and results of fertility preservation (FP) in patients with malignant and borderline ovarian tumors. Consecutive cohort study of 43 women with malignant or borderline ovarian tumors who underwent FP between February 2013 and July 2019. The study was conducted in national expert center in Tenon University Hospital, Sorbonne University: French ESGO-certified ovarian cancer center and pregnancy-associated cancer network (CALG). Main outcome measure was FP technique proposed by multidisciplinary committee, FP technique used, time after surgery, number of fragments, histology and follicle density (if ovarian tissue freezing), number of expected, retrieved and frozen oocytes (if ovarian stimulation). Pathological diagnosis was malignant epithelial ovarian tumor in five women (11.6%), rare malignant ovarian tumor in 14 (32.6%), borderline in 24 (55.8%), and mostly unilateral (79.1%) and stage I (76.7%). Mean age at diagnosis was 26.8 ± 6.9 years and mean tumor size 109.7 ± 61 mm. Before FP, mean AFC was 11.0 ± 6.1 and AMH levels were 2.7 ± 4.6 ng/mL. Six ovarian tissue-freezing procedures were performed (offered to 13). Twenty-four procedures of ovarian stimulation and oocyte freezing were performed after surgical treatment for 19 women (offered to 28) with a median interval of 188 days. The mean number of mature oocytes retrieved per stimulation was 12.4 ± 12.8. At least 10 mature oocytes were frozen for 52.6% of the women. No FP was offered to five women. Oocyte and ovarian tissue cryopreservation should be offered to patients with malignant and borderline ovarian tumors. More data are needed to confirm ovarian stimulation and ovarian tissue grafting safety. •The median number of ovarian tissue frozen fragments was 22 per patient•In mature oocyte vitrification after ovarian stimulation ten or more frozen oocytes were obtained in 55.6% patients•Preoperative fertility preservation consultations increased from 0% in 2013 to 67% in 2019•Only 28.6% of the patients declined ovarian stimulation for oocyte cryopreservation