Details

Autor(en) / Beteiligte

• Michowitz, Yoav
• Milman, Anat
• Sarquella-Brugada, Georgia
• Andorin, Antoine
• Champagne, Jean
• Postema, Pieter G.
• Casado-Arroyo, Ruben
• Leshem, Eran
• Juang, Jimmy J.M.
• Giustetto, Carla
• Tfelt-Hansen, Jacob
• Wijeyeratne, Yanushi D.
• Veltmann, Christian
• Corrado, Domenico
• Kim, Sung-Hwan
• Delise, Pietro
• Maeda, Shingo
• Gourraud, Jean-Baptiste
• Sacher, Frederic
• Mabo, Philippe
• Takahashi, Yoshihide
• Kamakura, Tsukasa
• Aiba, Takeshi
• Conte, Giulio
• Hochstadt, Aviram
• Mizusawa, Yuka
• Rahkovich, Michael
• Arbelo, Elena
• Huang, Zhengrong
• Denjoy, Isabelle
• Napolitano, Carlo
• Brugada, Ramon
• Calo, Leonardo
• Priori, Silvia G.
• Takagi, Masahiko
• Behr, Elijah R.
• Gaita, Fiorenzo
• Yan, Gan-Xin
• Brugada, Josep
• Leenhardt, Antoine
• Wilde, Arthur A.M.
• Brugada, Pedro
• Kusano, Kengo F.
• Hirao, Kenzo
• Nam, Gi-Byoung
• Probst, Vincent
• Belhassen, Bernard

Titel

Fever-related arrhythmic events in the multicenter Survey on Arrhythmic Events in Brugada Syndrome

Ist Teil von

• Heart rhythm, 2018-09, Vol.15 (9), p.1394-1401

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Quelle

MEDLINE

Beschreibungen/Notizen

• The literature on fever-related arrhythmic events (AEs) in Brugada syndrome (BrS) is currently limited to few case reports and small series. The present study aimed to describe the characteristics of fever-related AE in a large cohort of patients with BrS. The Survey on Arrhythmic Events in Brugada Syndrome is a multicenter study on 678 patients with BrS with first AE documented at the time of aborted cardiac arrest (n = 426) or after prophylactic implantable cardioverter-defibrillator implantation (n = 252). In 35 of 588 patients (6%) with available information, the AE occurred during a febrile illness. Most of the 35 patients were male (80%), Caucasian (83%), and proband (70%). The mean age at the time of AE was 29 ± 24 years (range 0.3–76 years). Most patients (80%) presented with aborted cardiac arrest and 6 (17%) with arrhythmic storm. Family history of sudden death, history of syncope, and spontaneous type 1 Brugada electrocardiogram were noted in 17%, 40%, and 71% of patients, respectively. Ventricular fibrillation was induced at electrophysiology study in 9 of 19 patients (47%). An SCN5A mutation was found in 14 of 28 patients (50%). The highest proportion of fever-related AE was observed in the pediatric population (age <16 years), with a disproportionally higher event rate in the very young (age 0–5 years) (65%). Males were involved in all age groups and females only in the pediatric and elderly groups. Fever-related AE affected 17 Caucasians aged <24 years, but no Asians aged <24 years. The risk of fever-related AE in BrS markedly varies according to age group, sex, and ethnicity. Taking these factors into account could help the clinical management of patients with BrS with fever.