Details

Autor(en) / Beteiligte

• Hénique, Carole
• Papista, Christina
• Guyonnet, Léa
• Lenoir, Olivia
• Tharaux, Pierre-Louis

Titel

Update on crescentic glomerulonephritis

Ist Teil von

• Seminars in immunopathology, 2014-07, Vol.36 (4), p.479-490

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2014

Quelle

SpringerLink

Beschreibungen/Notizen

• The recent years have seen a number of major progresses in the field of extracapillary glomerulonephritis. This entity is the final damage caused by unrelated immunological disorders such as immune complexes glomerular deposits or microvascular injury caused by proinflammatory cytokines, neutrophil extracellular traps (NET), and cell adhesion molecules in the context of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). This review provides a summary of recent advances in the understanding of crescentic glomerulonephritis, focusing on interplays of local immune cells and on local mediators participating to crescent formation especially in anti-glomerular basement membrane (anti-GBM) antibody disease. The recent advances about AAV and lupus nephritis are covered by other chapters of this issue. Nevertheless, these considerations may apply to the general case of crescentic glomerulonephritis of all causes.