Details

Autor(en) / Beteiligte

• Brouard, Jacques
• Knauer, Nicola
• Boelle, Pierre-Yves
• Corvol, Harriet
• Henrion-Caude, Alexandra
• Flamant, Cyril
• Bremont, François
• Delaisi, Bertrand
• Duhamel, Jean-Francois
• Marguet, Christophe
• Roussey, Michel
• Miesch, Marie-Claude
• Chadelat, Katarina
• Boule, Michele
• Fauroux, Brigitte
• Ratjen, Felix
• Grasemann, Hartmut
• Clement, Annick

Titel

Influence of Interleukin-10 on Aspergillus fumigatus Infection in Patients with Cystic Fibrosis

Ist Teil von

• The Journal of infectious diseases, 2005-06, Vol.191 (11), p.1988-1991

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

2005

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Recent evidence suggests that genetic polymorphisms that affect the production of interleukin (IL)–10 may play a role in the response to pathogens in cystic fibrosis (CF). The present study was designed to investigate a possible association between alleles carried at position −1082 in the promoter region of the IL-10 gene and clinical data on 378 patients with CF. After adjustment for potential confounding variables, a significant relationship was found between the −1082GG genotype and both colonization with Aspergillus fumigatus and allergic bronchopulmonary aspergillosis. In addition, higher serum levels of IL-10 were observed in patients colonized with A. fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF