Details

Autor(en) / Beteiligte

• Hagège, Albert A
• Carrion, Claire
• Menasché, Philippe
• Vilquin, Jean-Thomas
• Duboc, Denis
• Marolleau, Jean-Pierre
• Desnos, Michel
• Bruneval, Patrick

Titel

Viability and differentiation of autologous skeletal myoblast grafts in ischaemic cardiomyopathy

Ist Teil von

• The Lancet (British edition), 2003-02, Vol.361 (9356), p.491-492

Ort / Verlag

London: Elsevier Ltd

Erscheinungsjahr

2003

Quelle

EBSCO - Psychology & Behavioral Sciences Collection

Beschreibungen/Notizen

• Autologous skeletal myoblast transplantation might improve postinfarction ventricular function, but graft viability and differentiation (ie, proof of concept) has not been shown. A 72-year-old man had autologous cultured myoblasts from his vastus lateralis injected to an area of transmural inferior myocardial infarction in non-reperfused scar tissue. He showed improvement in symptoms and left-ventricular ejection fraction. When he died 17·5 months after the procedure, the grafted post-infarction scar showed well developed skeletal myotubes with a preserved contractile apparatus. 65% of myotubes expressed the slow myosin isoform and 33% coexpressed the slow and fast isoforms ( vs 44% and 0·6%, respectively, in skeletal muscle). Myoblast grafts can survive and show a switch to slow-twitch fibres, which might allow sustained improvement in cardiac function.