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The strong impact of population increase and the effects of climate change on drinking-water resources mean that it is essential to optimize the management of groundwater. This study aims at determining the best way of sustainably exploiting a well field south of Bordeaux (France). Currently, the field’s 18 wells can produce about 10 million (M) m
3
/year. Starting from a complete review of field data, this study presents an optimization method with surrogate models based on a preexisting spatially distributed groundwater model. This uses ‘influence coefficient’ methods for designing an efficient strategy to exploit groundwater, while preserving it from aquifer dewatering. This optimization approach investigates a much larger number of combinations than the classic trial-and-error approach. Though it is usually considered that preserving groundwater quality necessarily implies restricted exploitation, this work shows that other exploitation strategies can reach this objective with a significant gain in the total extracted volume without creating new wells. Two alternative configurations, incorporating the creation of new wells, were tested for maximizing the capacity of the well field and optimizing the effective capacity of the existing pipe network. Substantial gains are expected from those configurations, reaching an additional 2.2–5.5 M m
3
/year.