Details

Autor(en) / Beteiligte

• Bouisset, Frédéric
• Gerbaud, Edouard
• Bataille, Vincent
• Coste, Pierre
• Puymirat, Etienne
• Belle, Loic
• Delmas, Clément
• Cayla, Guillaume
• Motreff, Pascal
• Lemesle, Gilles
• Aissaoui, Nadia
• Blanchard, Didier
• Schiele, François
• Simon, Tabassome
• Danchin, Nicolas
• Ferrières, Jean

Titel

Percutaneous Myocardial Revascularization in Late-Presenting Patients With STEMI

Ist Teil von

• Journal of the American College of Cardiology, 2021-09, Vol.78 (13), p.1291-1305

Ort / Verlag

United States: Elsevier

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• The optimal management of patients with ST-segment elevation myocardial infarction (STEMI) presenting late->12 hours following symptom onset-is still under debate. The purpose of this study was to describe characteristics, temporal trends, and impact of revascularization in a large population of latecomer STEMI patients. The authors analyzed the data of 3 nationwide observational studies from the FAST-MI (French Registry of Acute ST-elevation and non-ST-elevation Myocardial Infarction) program, conducted over a 1-month period in 2005, 2010, and 2015. Patients presenting between 12 and 48 hours after symptom onset were classified as latecomers. A total of 6,273 STEMI patients were included in the 3 cohorts, 1,169 (18.6%) of whom were latecomers. After exclusion of patients treated with fibrinolysis and patients deceased within 2 days after admission, 1,077 patients were analyzed, of whom 729 (67.7%) were revascularized within 48 hours after hospital admission. At 30-day follow-up, all-cause death rate was significantly lower among revascularized latecomers (2.1% vs 7.2%; P < 0.001). After a median follow-up of 58 months, the rate of all-cause death was 30.4 (95% CI: 25.7-35.9) per 1,000 patient-years in the revascularized latecomers group vs 78.7 (95% CI: 67.2-92.3) per 1,000 patient-years in the nonrevascularized latecomers group (P < 0.001). In multivariate analysis, revascularization of latecomer STEMI patients was independently associated with a significant reduction of mortality occurrence during follow-up (HR: 0.65 [95% CI: 0.50-0.84]; P = 0.001). Coronary revascularization of latecomer STEMI patients is associated with better short and long-term clinical outcomes.