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Breast cancer revisited using DNA array‐based gene expression profiling
International journal of cancer, 2003-02, Vol.103 (5), p.565-571
Bertucci, François
Viens, Patrice
Hingamp, Pascal
Nasser, Valery
Houlgatte, Rémi
Birnbaum, Daniel
2003
Details
Autor(en) / Beteiligte
Bertucci, François
Viens, Patrice
Hingamp, Pascal
Nasser, Valery
Houlgatte, Rémi
Birnbaum, Daniel
Titel
Breast cancer revisited using DNA array‐based gene expression profiling
Ist Teil von
International journal of cancer, 2003-02, Vol.103 (5), p.565-571
Ort / Verlag
New York: Wiley Subscription Services, Inc., A Wiley Company
Erscheinungsjahr
2003
Link zum Volltext
Quelle
Wiley Online Library Journals Frontfile Complete
Beschreibungen/Notizen
Breast cancer is a complex genetic disease characterized by the accumulation of multiple molecular alterations. The resulting clinical heterogeneity makes current diagnostic and therapeutic strategies less than perfectly adapted to each patient. Pathological and clinical factors are insufficient to capture the complex cascade of events that drive the clinical behavior of tumors. High‐throughput molecular technologies provide novel tools to tackle this complexity. In particular, DNA arrays allow the simultaneous and quantitative analysis of the mRNA expression levels of thousands of genes in a single assay. Potential applications are multiple in the cancer field and the first research results are promising; comprehensive gene expression profiles of breast tumors are providing insights into mammary oncogenesis and are revealing new tumor subgroups previously indistinguishable. Significant advances will be the identification of new diagnostic, prognostic and predictive biomarkers as well as the discovery of new potential therapeutic targets. This review presents recent applications of DNA arrays in breast cancer research and discusses some issues to address in the near future to allow the technology to reach its full potential. © 2002 Wiley‐Liss, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0020-7136
eISSN: 1097-0215
DOI: 10.1002/ijc.10867
Titel-ID: cdi_hal_primary_oai_HAL_hal_03623846v1
Format
–
Schlagworte
Biological and medical sciences
,
breast cancer
,
Breast Neoplasms - diagnosis
,
Breast Neoplasms - genetics
,
Breast Neoplasms - therapy
,
Cancer
,
DNA microarray
,
DNA, Neoplasm - analysis
,
Female
,
Female genital diseases
,
Gene Expression Profiling
,
Gynecology. Andrology. Obstetrics
,
Humans
,
Life Sciences
,
Medical sciences
,
Neoplasm Proteins - genetics
,
Oligonucleotide Array Sequence Analysis
,
prognosis
,
RNA, Messenger - metabolism
,
Tumors
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