Details

Autor(en) / Beteiligte

• Gaudry, Stéphane
• Hajage, David
• Schortgen, Fréderique
• Martin-Lefevre, Laurent
• Pons, Bertrand
• Boulet, Eric
• Boyer, Alexandre
• Chevrel, Guillaume
• Lerolle, Nicolas
• Carpentier, Dorothée
• de Prost, Nicolas
• Lautrette, Alexandre
• Bretagnol, Anne
• Mayaux, Julien
• Nseir, Saad
• Megarbane, Bruno
• Thirion, Marina
• Forel, Jean-Marie
• Maizel, Julien
• Yonis, Hodane
• Markowicz, Philippe
• Thiery, Guillaume
• Tubach, Florence
• Ricard, Jean-Damien
• Dreyfuss, Didier

Titel

Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit

Ist Teil von

• The New England journal of medicine, 2016-07, Vol.375 (2), p.122-133

Ort / Verlag

United States: Massachusetts Medical Society

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• This multicenter randomized trial compared strategies of early and delayed renal-replacement therapy in patients with severe acute kidney injury. There was no significant difference in mortality, the primary outcome, between the study groups. Acute kidney injury is a common condition among patients in the intensive care unit 1 – 4 and is associated with high morbidity and mortality. 2 , 5 – 8 Renal-replacement therapy is the cornerstone of the management of severe acute kidney injury. Many studies have focused on methods of renal-replacement therapy, 5 , 6 , 8 , 9 but the issue of when to initiate the therapy in the absence of a potentially life-threatening complication directly related to renal failure remains a subject of debate. Indirect evidence has suggested that early renal-replacement therapy could confer a survival benefit. 10 – 12 However, two observational studies reported high survival rates among . . .