Details

Autor(en) / Beteiligte

• Boilève, Alice
• Contejean, Adrien
• Barreau, Sylvain
• Sourdeau, Élise
• Friedrich, Chloé
• Kosmider, Olivier
• Burroni, Barbara
• Dupin, Nicolas
• Lheure, Coralie
• Rossignol, Julien
• Bouscary, Didier
• Grignano, Éric

Titel

Mastocytosis onset in a patient with treated hairy cell leukemia: Just a coincidence?

Ist Teil von

• Blood cells, molecules, & diseases, 2020-03, Vol.81, p.102392-102392, Article 102392

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• Mastocytosis is a mast cell disease caused by functionally defective infiltrating mast cells and CD34+ mast cell precursors. The heterogeneous group of mast cell disorders is categorized into five variants in the updated 2017 World Health Organization (WHO) classification among those systemic mastocytosis with an associated neoplasm (SM-AHN). Except for myeloid neoplasia, lymphoproliferative disorders associated to SM-AHN are more scarce. Here, we report the second case ever described of associated mastocytosis and hairy-cell disease. A 38-year-old female patient without any specific medical history was diagnosed a hairy cell leukemia and BRAFV600E mutation was found in hairy cells. Since purine-analogs were avoided to prevent prolonged myelosuppression, she was treated with vemurafenib and rituximab. Despite early discontinuation due to vemurafenib-induced agranulocytosis, a partial response was observed. Strikingly, bone marrow biopsy performed one month after vemurafenib discontinuation revealed a nodular infiltration by 30% tumoral mastocytes. Along with elevated tryptase level, KITD816V mutation on mastocytes and clinical exam, the patient was diagnosed with systemic mastocytosis with an associated hematological neoplasm (SM-AHN). No BRAFV600E mutation was found on mastocytes. The physiopathology of this association is not known and might be only a coincidence or a common genetic driver mutation enhancing mast and hairy cells. •Lymphoproliferative disorders associated to systemic mastocytosis are rare.•We report the second case so far of associated mastocytosis and hairy-cell disease.•BRAFV600E mutation was found in hairy cells and not in mast cells.•KITD816V mutation was found in mastocytes and not in hairy cells.•The physiopathology of this association is not known.