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Inherited ichthyoses are genetic disorders of cornification characterised by scaling of various aspects and severity, often associated with erythroderma. The skin is usually uncomfortable, pruriginous and painful and no specific treatment is available. Impact on quality of life (QoL) was previously demonstrated. QoL is a dynamic process that can be defined as an individual perception of one’s position in life. In order to improve patient’s management, the aim of our study was to determine the impact of weighted factors associated with impaired QoL in adult ichthyosis patients.