Details

Autor(en) / Beteiligte

• Dupré, Elian
• Clantin, Bernard
• Yuan, Youhua
• Lecher, Sophie
• Lesne, Elodie
• Antoine, Rudy
• Villeret, Vincent
• Jacob-Dubuisson, Françoise

Titel

Structural insight into the role of the PAS domain for signal transduction in sensor-kinase BvgS

Ist Teil von

• Journal of bacteriology, 2021-05

Ort / Verlag

American Society for Microbiology

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus flytrap (VFT) domains. The VFT domains are connected to the cytoplasmic kinase moiety by helical linkers separated by a Per-ARNT-Sim (PAS) domain. Antagonism between the two linkers, as one forms a coiled coil when the other is dynamic and vice versa, regulates BvgS activity. Here we solved the structure of the intervening PAS domain by X-ray