Details

Autor(en) / Beteiligte

• Lacerda, Sara
• Delalande, Anthony
• Eliseeva, Svetlana V.
• Pallier, Agnès
• Bonnet, Célia S.
• Szeremeta, Frédéric
• Même, Sandra
• Pichon, Chantal
• Petoud, Stéphane
• Tóth, Éva

Titel

Doxorubicin‐Sensitized Luminescence of NIR‐Emitting Ytterbium Liposomes: Towards Direct Monitoring of Drug Release

Ist Teil von

• Angewandte Chemie International Edition, 2021-10, Vol.60 (44), p.23574-23577

Auflage

International ed. in English

Ort / Verlag

Germany: Wiley Subscription Services, Inc

Erscheinungsjahr

2021

Quelle

MEDLINE

Beschreibungen/Notizen

• Drug‐loaded liposomes are typical examples of nanomedicines. We show here that doxorubicin, the anti‐cancer agent in the liposomal drug Doxil, can sensitize Ytterbium (Yb3+) and generate its near‐infrared (NIR) emission. When doxorubicin and amphiphilic Yb3+ chelates are incorporated into liposomes, the sensitized emission of Yb3+ is dependent on the integrity of the particles, which can be used to monitor drug release. We also established the first demonstration that the NIR Yb3+ emission signal is observable in living mice following intratumoral injection of the Yb3+‐doxorubicin‐liposomes, using a commercial macroscopic setup equipped with a NIR camera. Doxorubicin‐sensitized near‐infrared (NIR) emission of Yb3+ is observable in solutions of liposomes encapsulating the drug and amphiphilic Yb3+ complexes. This emission vanishes when the liposome is destroyed and doxorubicin is released. The NIR Yb3+ luminescence could be observed in living mice with a commercial macroscopic setup.