Details

Autor(en) / Beteiligte

• Annweiler, C.
• Milea, D.
• Whitson, H. E.
• Cheng, C.‐Y.
• Wong, T.‐Y.
• Ikram, M. K.
• Lamoureux, E. L.
• Sabanayagam, C.

Titel

Vitamin D insufficiency and cognitive impairment in Asians: a multi‐ethnic population‐based study and meta‐analysis

Ist Teil von

• Journal of internal medicine, 2016-09, Vol.280 (3), p.300-311

Ort / Verlag

England: Wiley

Erscheinungsjahr

2016

Quelle

MEDLINE

Beschreibungen/Notizen

• Background The relationship between vitamin D insufficiency and cognitive impairment remains equivocal in Asians. We examined the association between circulating 25‐hydroxyvitamin D (25OHD) concentration and cognitive performance in a large multi‐ethnic Singaporean population‐based study. We also conducted a meta‐analysis of 25OHD concentrations amongst cognitively impaired older adults in Asia. Methods Our population‐based cross‐sectional study included 2273 persons ≥60 years of age from the Singapore Epidemiology of Eye Diseases (SEED) study (mean ± SD age 70.4 ± 6.2 years; 44.7% female), who were categorized according to 25OHD concentration (i.e. ≤10, 10.1–20 and >20 ng mL−1). The 25OHD concentration was measured and adjusted to reflect a deseasonalized value. Cognition was assessed using the total and domain scores of the Abbreviated Mental Test (AMT). Global cognitive impairment was defined as AMT score of ≤6 if 0–6 years of education and AMT score of ≤8 if >7 years of education. Fully adjusted multivariate models were used. We included seven studies in a meta‐analysis of 25OHD and cognition in Asia (6068 participants; 1179 cognitively impaired cases). Results Participants with 25OHD levels >20 ng mL−1 (n = 1302) had higher AMT total scores (mean ± SD 8.5 ± 1.9) and were less likely to have cognitive impairment (14.1%) than participants with lower 25OHD levels (overall P < 0.001, P‐trend < 0.001). Deseasonalized 25OHD concentration was associated with AMT score (β = 0.10 per 10 ng mL−1, P = 0.035). Vitamin D insufficiency (25OHD ≤20 ng mL−1) was associated with global cognitive impairment (OR 1.56, P = 0.028). Specifically, 25OHD concentration correlated with semantic memory (r = 0.08, P = 0.009) and orientation in time (r = 0.09, P = 0.003). In the meta‐analysis, the pooled mean 25OHD difference was −6.83 ng mL−1 (95% confidence interval −11.36; −2.30), indicating lower 25OHD concentrations amongst cognitively impaired compared to cognitively healthy participants in Asia. Conclusion Vitamin D insufficiency is associated with a greater likelihood of and more severe cognitive impairment in Asian populations.