Details

Autor(en) / Beteiligte

• Letournel, F
• Cassereau, J
• Scherer-Gagou, C
• Bernard, I
• Mercat, A
• Gray, F
• Tanguy, J.Y
• Richard-Crémieux, I
• Jeanfaivre, Th
• Barthelaix, A
• Dubas, F

Titel

An autopsy case of acute multiple sclerosis (Marburg's type) during pregnancy

Ist Teil von

• Clinical neurology and neurosurgery, 2008-05, Vol.110 (5), p.514-517

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract We report a case of a 9-month pregnant woman who presented acute psychiatric and neurological symptoms with extensive involvement of the white matter on MRI and no oligoclonal bands on CSF examination. Despite high doses of intravenous steroids, plasmapheresis and immunosuppressive drugs, a fatal outcome (coma) was noted 8 months later. Neuropathological examination confirmed the diagnosis of Marburg's type of multiple sclerosis showing sharp-edged lesions of demyelination, giant astrocytes, numerous macrophages and little perivascular inflammation. We discuss the definition and limits of the Marburg entity with reference to acute disseminated encephalomyelitis, impact of pregnancy, unusual MRI features, neuropathology and treatment.