Details

Autor(en) / Beteiligte

• Miller, Joseph D.
• van der Most, Robbert G.
• Akondy, Rama S.
• Glidewell, John T.
• Albott, Sophia
• Masopust, David
• Murali-Krishna, Kaja
• Mahar, Patryce L.
• Edupuganti, Srilatha
• Lalor, Susan
• Germon, Stephanie
• Del Rio, Carlos
• Mulligan, Mark J.
• Staprans, Silvija I.
• Altman, John D.
• Feinberg, Mark B.
• Ahmed, Rafi

Titel

Human Effector and Memory CD8 + T Cell Responses to Smallpox and Yellow Fever Vaccines

Ist Teil von

• Immunity (Cambridge, Mass.), 2008-05, Vol.28 (5), p.710-722

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2008

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• To explore the human T cell response to acute viral infection, we performed a longitudinal analysis of CD8 + T cells responding to the live yellow fever virus and smallpox vaccines—two highly successful human vaccines. Our results show that both vaccines generated a brisk primary effector CD8 + T cell response of substantial magnitude that could be readily quantitated with a simple set of four phenotypic markers. Secondly, the vaccine-induced T cell response was highly specific with minimal bystander effects. Thirdly, virus-specific CD8 + T cells passed through an obligate effector phase, contracted more than 90% and gradually differentiated into long-lived memory cells. Finally, these memory cells were highly functional and underwent a memory differentiation program distinct from that described for human CD8 + T cells specific for persistent viruses. These results provide a benchmark for CD8 + T cell responses induced by two of the most effective vaccines ever developed.