Details

Autor(en) / Beteiligte

• van Bohemen, Anne-Isaline
• Ruiz, Nicolas
• Zalouk-Vergnoux, Aurore
• Michaud, Aurore
• Robiou du Pont, Thibaut
• Druzhinina, Irina
• Atanasova, Lea
• Prado, Soizic
• Bodo, Bernard
• Meslet-Cladiere, Laurence
• Cochereau, Bastien
• Bastide, Franck
• Maslard, Corentin
• Marchi, Muriel
• Guillemette, Thomas
• Pouchus, Yves François

Titel

Pentadecaibins I–V: 15-Residue Peptaibols Produced by a Marine-Derived Trichoderma sp. of the Harzianum Clade

Ist Teil von

• Journal of natural products (Washington, D.C.), 2021-04, Vol.84 (4), p.1271-1282

Ort / Verlag

United States: American Chemical Society and American Society of Pharmacognosy

Erscheinungsjahr

2021

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• In the course of investigations on peptaibol chemodiversity from marine-derived Trichoderma spp., five new 15-residue peptaibols named pentadecaibins I–V (1–5) were isolated from the solid culture of the strain Trichoderma sp. MMS1255 belonging to the T. harzianum species complex. Phylogenetic analyses allowed precise positioning of the strain close to T. lentiforme lineage inside the Harzianum clade. Peptaibol sequences were elucidated on the basis of their MS/MS fragmentation and extensive 2D NMR experiments. Amino acid configurations were determined by Marfey’s analyses. The pentadecaibins are based on the sequences Ac-Aib1-Gly2-Ala3-Leu4-Aib/Iva5-Gln6-Aib/Iva7-Val/Leu8-Aib9-Ala10-Aib11-Aib12-Aib13-Gln14-Pheol15. Characteristic of the pentadecaibin sequences is the lack of the Aib-Pro motif commonly present in peptaibols produced by Trichoderma spp. Genome sequencing of Trichoderma sp. MMS1255 allowed the detection of a 15-module NRPS-encoding gene closely associated with pentadecaibin biosynthesis. Pentadecaibins were assessed for their potential antiproliferative and antimicrobial activities.